Human PI3 Recombinant Protein (RPPB4246)

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SKU:
RPPB4246
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PI3
Synonyms:
Elafin
Synonyms:
ESI
Synonyms:
SKALP
Synonyms:
WAP3
Source:
Sf9 Insect cells
Uniprot:
P19957
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Description

Product Name:Human PI3 Recombinant Protein
Product Code:RPPB4246
Size:10µg
Species:Human
Target:PI3
Synonyms:Elafin, ESI, SKALP, WAP3, WFDC14.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PI3 solution (0.2mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:AVTGVPVKGQ DTVKGRVPFN GQDPVKGQVS VKGQDKVKAQ EPVKGPVSTK PGSCPIILIR CAMLNPPNRC LKDTDCPGIK KCCEGSCGMA CFVPQHHHHH H

Peptidase Inhibitor 3, also referred to PI3, is neutrophil and pancreatic elastase-specific inhibitor of skin. The protein may prevent elastase mediated tissue proteolysis. PI3 has shown inhibition of alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor, a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1.

PI3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 101 amino acids (23-117a.a) and having a molecular mass of 10.7kDa.PI3 is fused to an 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
UniProt Protein Details:

Protein type:Extracellular matrix; Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: proteinaceous extracellular matrix

Molecular Function:serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: copulation

NCBI Summary:This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]
UniProt Code:P19957
NCBI GenInfo Identifier:119262
NCBI Gene ID:5266
NCBI Accession:P19957.3
UniProt Secondary Accession:P19957,Q6FG74, E1P618,
UniProt Related Accession:P19957
Molecular Weight:12,270 Da
NCBI Full Name:Elafin
NCBI Synonym Full Names:peptidase inhibitor 3, skin-derived
NCBI Official Symbol:PI3  
NCBI Official Synonym Symbols:ESI; WAP3; SKALP; WFDC14; cementoin  
NCBI Protein Information:elafin; PI-3; trappin-2; pre-elafin; protease inhibitor WAP3; elastase-specific inhibitor; skin-derived antileukoproteinase; WAP four-disulfide core domain 14; WAP four-disulfide core domain protein 14; protease inhibitor 3, skin-derived (SKALP)
UniProt Protein Name:Elafin
UniProt Synonym Protein Names:Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14
Protein Family:Elafin
UniProt Gene Name:PI3  
UniProt Entry Name:ELAF_HUMAN
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