Human PHLDA2 Recombinant Protein (RPPB4244)

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SKU:
RPPB4244
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PHLDA2
Synonyms:
Pleckstrin homology-like domain family A member 2
Synonyms:
Imprinted in placenta and liver protein
Synonyms:
Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
Synonyms:
Tumor-suppressing STF cDNA 3 protein
Source:
Escherichia Coli
Uniprot:
Q53GA4
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Description

Product Name:Human PHLDA2 Recombinant Protein
Product Code:RPPB4244
Size:10µg
Species:Human
Target:PHLDA2
Synonyms:Pleckstrin homology-like domain family A member 2, Imprinted in placenta and liver protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, Tumor-suppressing STF cDNA 3 protein, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, p17-Beckwith-Wiedemann region 1 C, PHLDA2, BWR1C, HLDA2, IPL, TSSC3, BRW1C.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:PHLDA2 solution containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol 0.1M NaCl and 1mM DTT.
Stability:PHLDA2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP

Pleckstrin homology-like domain family A member 2 (PHLDA2) is a cytoplasmic protein, which is involved in fetal and placental growth. PHLDA2 is an apoptosis-related protein, which acts as a negative growth regulator and is expressed during normal human development. PHLDA2 is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete. The PHLDA2 gene is one of a number of genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Changes in this region may be linked to the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHLDA2 is expressed in placenta (present in all cells of the villous cytotrophoblast) and adult prostate gland. Furthermore, PHLDA2 is expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines and at low levels in adult liver and lung, and fetal liver.

PHLDA2 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 172 amino acids (1-152 a.a.) and having a molecular mass of 19.2 kDa. PHLDA2 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:PHLDA2: a protein may play a role in regulating placenta growth. Contains one PH domain. Expressed in placenta and adult prostate gland. Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Biological Process: apoptosis

NCBI Summary:This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
UniProt Code:Q53GA4
NCBI GenInfo Identifier:84029394
NCBI Gene ID:7262
NCBI Accession:Q53GA4.2
UniProt Secondary Accession:Q53GA4,O00496,
UniProt Related Accession:Q53GA4
Molecular Weight:17,092 Da
NCBI Full Name:Pleckstrin homology-like domain family A member 2
NCBI Synonym Full Names:pleckstrin homology like domain family A member 2
NCBI Official Symbol:PHLDA2  
NCBI Official Synonym Symbols:IPL; BRW1C; BWR1C; HLDA2; TSSC3  
NCBI Protein Information:pleckstrin homology-like domain family A member 2
UniProt Protein Name:Pleckstrin homology-like domain family A member 2
UniProt Synonym Protein Names:Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C
Protein Family:Pleckstrin homology-like domain family
UniProt Gene Name:PHLDA2  
UniProt Entry Name:PHLA2_HUMAN
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