Human PFDN4 Recombinant Protein (RPPB4230)
- SKU:
- RPPB4230
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PFDN4
- Synonyms:
- Prefoldin Subunit 4
- PFD4
- C1
- Prefoldin 4
- Source:
- Escherichia Coli
- Uniprot:
- Q9NQP4
Description
| Product Name: | Human PFDN4 Recombinant Protein |
| Product Code: | RPPB4230 |
| Size: | 10µg |
| Species: | Human |
| Target: | PFDN4 |
| Synonyms: | Prefoldin Subunit 4, PFD4, C1, Prefoldin 4, Protein C-1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The PFDN4 protein solution (1mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH7.5), 50mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA LESRVESIQR VLADLKVQLY AKFGSNINLE ADES |
PFDN4 belongs to the prefoldin beta subunit family. PFDN4 is a heterohexameric chaperone protein that can capture unfolded actin and is a possible transcription factor. Six prefoldin polypeptides, prefoldin 1-6, are known.
PFDN4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids (1-134.a.a) and having a molecular mass of 17.4kDa. PFDN4 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PFDN4: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Belongs to the prefoldin subunit beta family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: mitochondrion; cytoplasm; nucleus; cytosol; prefoldin complex Molecular Function:protein binding; chaperone binding; unfolded protein binding Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding |
| NCBI Summary: | This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQP4 |
| NCBI GenInfo Identifier: | 12643815 |
| NCBI Gene ID: | 5203 |
| NCBI Accession: | Q9NQP4.1 |
| UniProt Secondary Accession: | Q9NQP4,Q5TD11, Q92779, |
| UniProt Related Accession: | Q9NQP4 |
| Molecular Weight: | Calculated: 15kDaObserved: 15kDa |
| NCBI Full Name: | Prefoldin subunit 4 |
| NCBI Synonym Full Names: | prefoldin subunit 4 |
| NCBI Official Symbol: | PFDN4 |
| NCBI Official Synonym Symbols: | C1; PFD4 |
| NCBI Protein Information: | prefoldin subunit 4; prefoldin 4; protein C-1 |
| UniProt Protein Name: | Prefoldin subunit 4 |
| UniProt Synonym Protein Names: | Protein C-1 |
| Protein Family: | Prefoldin |
| UniProt Gene Name: | PFDN4 |
| UniProt Entry Name: | PFD4_HUMAN |
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