Human PDZD11 Recombinant Protein (RPPB4218)

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SKU:
RPPB4218
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PDZD11
Synonyms:
PDZ domain-containing protein 11
Synonyms:
ATPase-interacting PDZ protein
Synonyms:
Plasma membrane calcium ATPase-interacting single-PDZ protein
Synonyms:
PMCA-interacting single-PDZ protein
Source:
Escherichia Coli
Uniprot:
Q5EBL8
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Description

Product Name:Human PDZD11 Recombinant Protein
Product Code:RPPB4218
Size:10µg
Species:Human
Target:PDZD11
Synonyms:PDZ domain-containing protein 11, ATPase-interacting PDZ protein, Plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein, PDZD11, AIPP1, PDZK11, PISP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PDZD11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDSRIPY DDYPVVFLPA YENPPAWIPP HERVHHPDYN NELTQFLPRT ITLKKPPGAQ LGFNIRGGKA SQLGIFISKV IPDSDAHRAG LQEGDQVLAV NDVDFQDIEH SKAVEILKTA REISMRVRFF PYNYHRQKER TVH

PDZ Domain Containing 11 (PDZD11) is a cytosolic protein which contains one PDZ (DHR) domain. PDZD11 displays a resemblance to members of the MALS / VELIS family of proteins. PDZD11 contains but one PDZ domain which seemingly interacts with the C-terminus of partner proteins. PDZD11 is ubiquitously expressed and targets calcium and copper ATPases to basolateral cell membranes. PDZD11 is a briefly interacting partner of the PMCA b-splice forms which have a role in their sorting to or from the plasma membrane.

PDZD11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (1-140 a.a) and having a molecular mass of 18.5kDa.PDZD11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PDZD11: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: Xq13.1Cellular Component: basolateral plasma membrane; cytosol; intercellular junction; synapseMolecular Function: protein bindingBiological Process: antimicrobial humoral response; biotin metabolic process; maintenance of epithelial cell polarity; neurotransmitter secretion; pantothenate metabolic process; transmembrane transport
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q5EBL8
NCBI GenInfo Identifier:7706025
NCBI Gene ID:51248
NCBI Accession:NP_057568.1
UniProt Secondary Accession:Q5EBL8,Q6UWE1, Q9P0Q1, D3DVU3
UniProt Related Accession:Q5EBL8
Molecular Weight:32.1kD
NCBI Full Name:PDZ domain-containing protein 11
NCBI Synonym Full Names:PDZ domain containing 11
NCBI Official Symbol:PDZD11  
NCBI Official Synonym Symbols:PISP; AIPP1; PDZK11  
NCBI Protein Information:PDZ domain-containing protein 11
UniProt Protein Name:PDZ domain-containing protein 11
UniProt Synonym Protein Names:ATPase-interacting PDZ protein; Plasma membrane calcium ATPase-interacting single-PDZ protein; PMCA-interacting single-PDZ protein
Protein Family:PDZ domain-containing protein
UniProt Gene Name:PDZD11  
UniProt Entry Name:
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