Human PDXP Recombinant Protein (RPPB2089)
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주문- SKU:
- RPPB2089
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PDXP
- Synonyms:
- CIN
- Synonyms:
- PLP
- Synonyms:
- PLPP
- Synonyms:
- EC 31374
- Source:
- Escherichia Coli
- Uniprot:
- Q96GD0
Description
| Product Name: | Human PDXP Recombinant Protein |
| Product Code: | RPPB2089 |
| Size: | 10µg |
| Species: | Human |
| Target: | PDXP |
| Synonyms: | CIN, PLP, PLPP, EC 3.1.3.74. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 1mg/ml solution containing 20mM Tris pH-8, 1mM DTT, 0.1M NaCl & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MARCERLRGA ALRDVLGRAQ GVLFDCDGVL WNGERAVPGA PELLERLARA GKAALFVSNN SRRARPELAL RFARLGFGGL RAEQLFSSAL CAARLLRQRL PGPPDAPGAV FVLGGEGLRA ELRAAGLRLA GDPSAGDGAA PRVRAVLVGY DEHFSFAKLR EACAHLRDPE CLLVATDRDP WHPLSDGSRT PGTGSLAAAV ETASGRQALV VGKPSPYMFE CITENFSIDP ARTLMVGDRL ETDILFGHRC GMTTVLTLTG VSRLEEAQAY LAAGQHDLVP HYYVESIADL TEGLED |
PDXP is the active form of vitamin B6 that functions as a coenzyme in preserving biochemical homeostasis. The desired degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP. PDXP shows activity to pyridoxal 5''-phosphate (PLP), pyridoxine 5''-phosphate (PMP) and Pyridoxine 5''-phosphate (PNP), with a highest activity with PLP followed by PNP.
PDXP Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-296 a.a.) and having a molecular mass of 33.8 kDa. The PDXP is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.3; EC 3.1.3.74; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: actin cytoskeleton; cleavage furrow; cytosol; lamellipodium; midbody; plasma membrane Molecular Function:heat shock protein binding; magnesium ion binding; phosphoprotein phosphatase activity; protein binding; pyridoxal phosphatase activity Biological Process: actin rod formation; positive regulation of actin filament depolymerization; protein amino acid dephosphorylation; pyridoxal phosphate catabolic process; regulation of cytokinesis; regulation of mitosis |
| NCBI Summary: | Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96GD0 |
| NCBI GenInfo Identifier: | 10092677 |
| NCBI Gene ID: | 57026 |
| NCBI Accession: | NP_064711.1 |
| UniProt Secondary Accession: | Q96GD0,Q9UGY2, |
| UniProt Related Accession: | Q96GD0 |
| Molecular Weight: | 33.7 kDa |
| NCBI Full Name: | pyridoxal phosphate phosphatase |
| NCBI Synonym Full Names: | pyridoxal phosphatase |
| NCBI Official Symbol: | PDXP |
| NCBI Official Synonym Symbols: | CIN; PLP; dJ37E16.5 |
| NCBI Protein Information: | pyridoxal phosphate phosphatase |
| UniProt Protein Name: | Pyridoxal phosphate phosphatase |
| UniProt Synonym Protein Names: | Chronophin |
| Protein Family: | Pyridoxal phosphate phosphatase |
| UniProt Gene Name: | PDXP |
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