Human PDGF-BB Recombinant Protein (RPES3218)
- SKU:
- RPES3218
- Product type:
- Recombinant Protein
- Host species:
- Yeast
- Reactivity:
- Human
Frequently bought together:
Description
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Human PDGF-BB Recombinant Protein
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
| Product Name: | Human PDGF-BB Recombinant Protein (RPES3218) |
| Product Code: | RPES3218 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | Yeast |
| Synonyms: | Platelet-Derived Growth Factor Subunit B, PDGF Subunit B, PDGF-2, Platelet-Derived Growth Factor B Chain, Platelet-Derived Growth Factor Beta Polypeptide, Proto-Oncogene c-Sis, Becaplermin, PDGFB, PDGF2, SIS |
| Accession: | NP_148937.1 |
| Sequence: | Ser82-Thr190 |
| Fusion tag: | N-His |
| Activity: | Measured by its binding ability in a functional ELISA.2.Immobilized human PDGFB at 10µg/mL (100?L/well) can bind human PDGFR?-Fch, the EC50 of human PDGFR?-Fch is 0.05-0.2 µg/mL. |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the human PDGFB (NP_148937.1) (Ser82-Thr190) was expressed with a polyhistidine tag at the N-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14.3 kDa |
| Formulation: | Lyophilized from sterile PBS, 25 % Glycerol, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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