Human PCSK9 Recombinant Protein (RPES2891)

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SKU:
RPES2891
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human PCSK9 Recombinant Protein

Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2); and play a role in the neural development.

Product Name:Human PCSK9 Recombinant Protein (RPES2891)
Product Code:RPES2891
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1
Accession:Q8NBP7
Sequence:Gln31-Gln152&Ser153-Gln692
Fusion tag:C-6His/HA/AVI
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His/HA/AVI tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:14&59
AP Mol Mass:18&70 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 50mM HEPES;150mM NaCl;20%Glycerol;pH 7.4.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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