Human PAX8 Recombinant Protein (RPPB4190)
- SKU:
- RPPB4190
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PAX8
- Synonyms:
- Paired Box 8
- Paired Box Gene 8
- PAX8
- Source:
- Escherichia Coli
- Uniprot:
- Q06710
Description
| Product Name: | Human PAX8 Recombinant Protein |
| Product Code: | RPPB4190 |
| Size: | 10µg |
| Species: | Human |
| Target: | PAX8 |
| Synonyms: | Paired Box 8, Paired Box Gene 8, PAX8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PAX8 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPHNSIR SGHGGLNQLG GAFVNGRPLP EVVRQRIVDL AHQGVRPCDI SRQLRVSHGC VSKILGRYYE TGSIRPGVIG GSKPKVATPK VVEKIGDYKR QNPTMFAWEI RDRLLAEGVC DNDTVPSVSS INRIIRTKVQ QPFNLPMDSC VATKSLSPGH TLIPSSAVTP PESPQSDSLG STYSINGLLG IAQPGSDKRK MDDSDQDSCR LSIDSQSSSS GPRKHLRTDA FSQHHLEPLE CPFERQHYPE AYASPSHTKG EQEVNTLAMP MATPPTPPTA RPGASPTPAC |
Paired box 8,also known as PAX8 functions in thyroid follicular cell development as well asin expression of thyroid-specific genes. PAX8 complexes with TTF-1& TTF-2 inorder to stimulate thyroid follicular cell differentiation and thyroid hormonebiosynthesis by regulating the expression of NIS (sodium iodide symporter) , TPO (thyroidperoxidase), TG (thyroglobulin) and the TSHR (thyrotropin receptor). Defects in PAX8 are the cause of CHNG2 (congenitalhypothyroidism non-goitrous type 2).
PAX8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids (1-287 a.a) and having a molecular mass of 33.4kDa.PAX8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q13 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity Biological Process: regulation of apoptosis; anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; mesonephros development; kidney development; pronephros development; urogenital system development Disease: Hypothyroidism, Congenital, Nongoitrous, 2 |
| NCBI Summary: | This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q06710 |
| NCBI GenInfo Identifier: | 215273928 |
| NCBI Gene ID: | 7849 |
| NCBI Accession: | Q06710.2 |
| UniProt Related Accession: | Q06710 |
| Molecular Weight: | 48kDa |
| NCBI Full Name: | Paired box protein Pax-8 |
| NCBI Synonym Full Names: | paired box 8 |
| NCBI Official Symbol: | PAX8 |
| NCBI Protein Information: | paired box protein Pax-8 |
| UniProt Protein Name: | Paired box protein Pax-8 |
| Protein Family: | Paired box protein |
| UniProt Gene Name: | PAX8 |
| UniProt Entry Name: | PAX8_HUMAN |
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