Human PARVA Recombinant Protein (RPPB4189)

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SKU:
RPPB4189
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PARVA
Synonyms:
Alpha-parvin
Synonyms:
Actopaxin
Synonyms:
CH-ILKBP
Synonyms:
Calponin-like integrin-linked kinase-binding protein
Source:
Escherichia Coli
Uniprot:
Q9NVD7
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Description

Product Name:Human PARVA Recombinant Protein
Product Code:RPPB4189
Size:20µg
Species:Human
Target:PARVA
Synonyms:Alpha-parvin, Actopaxin, CH-ILKBP, Calponin-like integrin-linked kinase-binding protein, Matrix-remodeling-associated protein 2, PARVA, MXRA2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PARVA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMATSPQK SPSVPKSPTP KSPPSRKKDD SFLGKLGGTL ARRKKAKEVS ELQEEGMNAI NLPLSPIPFE LDPEDTMLEE NEVRTMVDPN SRSDPKLQEL MKVLIDWIND VLVGERIIVK DLAEDLYDGQ VLQKLFEKLE SEKLNVAEVT QSEIAQKQKL QTVLEKINET LKLPPRSIKW NVDSVHAKSL VAILHLLVAL SQYFRAPIRL PDHVSIQVVV VQKREGILQS RQIQEEITGN TEALSGRHER DAFDTLFDHA PDKLNVVKKT LITFVNKHLN KLNLEVTELE TQFADGVYLV LLMGLLEGYF VPLHSFFLTP DSFEQKVLNV SFAFELMQDG GLEKPKPRPE DIVNCDLKST LRVLYNLFTK YRNVE

Alpha-parvin (PARVA) belongs to the parvin family of actin-binding proteins. PARVA has a role in the regulation of cell adhesion, cytoskeleton organization, motility and survival as well as in ciliogenesis. Parvins are related with focal contacts and contain calponin homology domains which connect to actin filaments. PARVA is extensively expressed, with the highest levels in heart, skeletal muscle, kidney and liver.

PARVA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-372 a.a) and having a molecular mass of 44.6kDa.PARVA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PARVA: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Adaptor/scaffoldChromosomal Location of Human Ortholog: 11p15.3Cellular Component: focal adhesion; lamellipodium; cytoplasm; plasma membrane; nucleus; Z disc; cytosol; actin cytoskeletonMolecular Function: protein binding; actin bindingBiological Process: heterotypic cell-cell adhesion; regulation of cell shape; actin cytoskeleton reorganization; establishment and/or maintenance of cell polarity; sprouting angiogenesis
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
UniProt Code:Q9NVD7
NCBI GenInfo Identifier:20139236
NCBI Gene ID:55742
NCBI Accession:Q9NVD7.1
UniProt Secondary Accession:Q9NVD7,Q96C85, Q9HA48
UniProt Related Accession:Q9NVD7
Molecular Weight:372
NCBI Full Name:Alpha-parvin
NCBI Synonym Full Names:parvin, alpha
NCBI Official Symbol:PARVA  
NCBI Official Synonym Symbols:MXRA2; CH-ILKBP  
NCBI Protein Information:alpha-parvin; actopaxin; matrix-remodeling-associated protein 2; calponin-like integrin-linked kinase-binding protein
UniProt Protein Name:Alpha-parvin
UniProt Synonym Protein Names:Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2
Protein Family:Parvalbumin
UniProt Gene Name:PARVA  
UniProt Entry Name:PARVA_HUMAN
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