Human PAFAH2 Recombinant Protein (RPPB2067)

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SKU:
RPPB2067
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PAFAH2
Synonyms:
HSD-PLA2
Synonyms:
Platelet-activating factor acetylhydrolase 2
Synonyms:
cytoplasmic
Synonyms:
Serine-dependent phospholipase A2
Source:
Escherichia Coli
Uniprot:
Q99487
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Description

Product Name:Human PAFAH2 Recombinant Protein
Product Code:RPPB2067
Size:20µg
Species:Human
Target:PAFAH2
Synonyms:HSD-PLA2, Platelet-activating factor acetylhydrolase 2,cytoplasmic, Serine-dependent phospholipase A2, SD-PLA2, hSD-PLA2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PAFAH2 protein solution (1mg/ml) in Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGVNQSV GFPPVTGPHL VGCGDVMEGQ NLQGSFFRLF YPCQKAEETMEQPLWIPRYE YCTGLAEYLQ FNKRCGGLLF NLAVGSCRLP VSWNGPFKTK DSGYPLIIFS HGLGAFRTLYSAFCMELASR GFVVAVPEHR DRSAATTYFC KQAPEENQPT NESLQEEWIP FRRVEEGEKE FHVRNPQVHQRVSECLRVLK ILQEVTAGQT VFNILPGGLD LMTLKGNIDM SRVAVMGHSF GGATAILALA KETQFRCAVALDAWMFPLER DFYPKARGPV FFINTEKFQT MESVNLMKKI CAQHEQSRII TVLGSVHRSQ TDFAFVTGNLIGKFFSTETR GSLDPYEGQE VMVRAMLAFL QKHLDLKEDY NQWNNLIEGI GPSLTPGAPH HLSSL

Platelet-activating factor acetylhydrolase 2 cytoplasmic (PAFAH2) has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. PAFAH2 may share a mutual physiologic function with the plasma-type enzyme.

PAFAH2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 415 amino acids (1-392 a.a) and having a molecular mass of 46.4kDa.PAFAH2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PAFAH2: Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. Belongs to the serine esterase family.
UniProt Protein Details:

Protein type:Hydrolase; Lipid-binding; EC 3.1.1.47; Lipid Metabolism - ether lipid

Chromosomal Location of Human Ortholog: 1p36

Molecular Function:phospholipid binding

Biological Process: lipid metabolic process

NCBI Summary:This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
UniProt Code:Q99487
NCBI GenInfo Identifier:6647691
NCBI Gene ID:5051
NCBI Accession:Q99487.1
UniProt Secondary Accession:Q99487,O15458, Q5SY02, D3DPK1,
UniProt Related Accession:Q99487
Molecular Weight:44,036 Da
NCBI Full Name:Platelet-activating factor acetylhydrolase 2, cytoplasmic
NCBI Synonym Full Names:platelet activating factor acetylhydrolase 2
NCBI Official Symbol:PAFAH2  
NCBI Official Synonym Symbols:HSD-PLA2  
NCBI Protein Information:platelet-activating factor acetylhydrolase 2, cytoplasmic
UniProt Protein Name:Platelet-activating factor acetylhydrolase 2, cytoplasmic
UniProt Synonym Protein Names:Serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2
Protein Family:Platelet-activating factor acetylhydrolase
UniProt Gene Name:PAFAH2  
UniProt Entry Name:PAFA2_HUMAN
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