Human OTUB2 Recombinant Protein (RPPB4175)

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SKU:
RPPB4175
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
OTUB2
Synonyms:
Ubiquitin thioesterase OTUB2
Synonyms:
Deubiquitinating enzyme OTUB2
Synonyms:
OTU domain-containing ubiquitin aldehyde-binding protein 2
Synonyms:
Otubain-2
Source:
Escherichia Coli
Uniprot:
Q96DC9
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Description

Product Name:Human OTUB2 Recombinant Protein
Product Code:RPPB4175
Size:25µg
Species:Human
Target:OTUB2
Synonyms:Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2, OTUB2, C14orf137, OTB2, OTU2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:OTUB2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 50mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK VFNDQSASDH IVQFLRLLTS AFIRNRADFF RHFIDEEMDI KDFCTHEVEP MATECDHIQI TALSQALSIA LQVEYVDEMD TALNHHVFPE AATPSVYLLY KTSHYNILYA ADKH

Ubiquitin thioesterase OTUB2 (OTUB2) is a member of the peptidase C65 family. OTUB2 functions as a hydrolase which can remove conjugated ubiquitin from proteins in vitro and may thus play a key regulatory role at the level of protein turnover by preventing degradation.

OTUB2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 254 amino acids (1-234 a.a.) and having a molecular mass of 29.4kDa.OTUB2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:OTUB2: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C65 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.19.12; Ubiquitin-specific protease; Hydrolase

Chromosomal Location of Human Ortholog: 14q32.12

Cellular Component: nucleus

Molecular Function:NEDD8-specific protease activity; protein binding; ubiquitin binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination

NCBI Summary:This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
UniProt Code:Q96DC9
NCBI GenInfo Identifier:44888285
NCBI Gene ID:78990
NCBI Accession:Q96DC9.2
UniProt Secondary Accession:Q96DC9,Q6IA10, Q9H6T1,
UniProt Related Accession:Q96DC9
Molecular Weight:8,637 Da
NCBI Full Name:Ubiquitin thioesterase OTUB2
NCBI Synonym Full Names:OTU deubiquitinase, ubiquitin aldehyde binding 2
NCBI Official Symbol:OTUB2  
NCBI Official Synonym Symbols:OTB2; OTU2; C14orf137  
NCBI Protein Information:ubiquitin thioesterase OTUB2
UniProt Protein Name:Ubiquitin thioesterase OTUB2
UniProt Synonym Protein Names:Deubiquitinating enzyme OTUB2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain-2; Ubiquitin-specific-processing protease OTUB2
Protein Family:Ubiquitin thioesterase
UniProt Gene Name:OTUB2  
UniProt Entry Name:OTUB2_HUMAN
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