Human OSCAR Recombinant Protein (RPPB4169)
- SKU:
- RPPB4169
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- OSCAR
- Synonyms:
- PIGR3
- Osteoclast-associated immunoglobulin-like receptor
- hOSCAR
- Polymeric immunoglobulin receptor 3
- Source:
- Escherichia Coli
- Uniprot:
- Q8IYS5
Frequently bought together:
Description
| Product Name: | Human OSCAR Recombinant Protein |
| Product Code: | RPPB4169 |
| Size: | 20µg |
| Species: | Human |
| Target: | OSCAR |
| Synonyms: | PIGR3, Osteoclast-associated immunoglobulin-like receptor, hOSCAR, Polymeric immunoglobulin receptor 3, OSCAR, PIgR-3, PIgR3, Poly-Ig receptor 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | OSCAR protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V |
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. OSCAR plays crucial roles in the regulation of the innate and adaptive immune responses.Unlike the other LRC members, OSCAR expression is found specifically in preosteoclasts or mature osteoclasts. OSCAR is an important bone-specific regulator of osteoclast differentiation. Multiple alternative splicing transcript variants encodes different isoforms have been found for this gene.
OSCAR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 291 amino acids (19-286 a.a.) and having a molecular mass of 31kDa.OSCAR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: plasma membrane; integral to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q8IYS5 |
| NCBI GenInfo Identifier: | 311033418 |
| NCBI Gene ID: | 126014 |
| NCBI Accession: | Q8IYS5.3 |
| UniProt Secondary Accession: | Q8IYS5,Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2 B7WNS2 |
| UniProt Related Accession: | Q8IYS5 |
| Molecular Weight: | 30,481 Da |
| NCBI Full Name: | Osteoclast-associated immunoglobulin-like receptor |
| NCBI Synonym Full Names: | osteoclast associated, immunoglobulin-like receptor |
| NCBI Official Symbol: | OSCAR |
| NCBI Official Synonym Symbols: | PIGR3; PIgR-3 |
| NCBI Protein Information: | osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2 |
| UniProt Protein Name: | Osteoclast-associated immunoglobulin-like receptor |
| UniProt Synonym Protein Names: | Polymeric immunoglobulin receptor 3 |
| Protein Family: | Protein |
| UniProt Gene Name: | OSCAR |
| UniProt Entry Name: | OSCAR_HUMAN |
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