Human Omentin Recombinant Protein (RPPB0814)
- SKU:
- RPPB0814
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- Omentin
- Synonyms:
- Intelectin-1
- HL1
- LFR
- HL-1
- Source:
- Escherichia Coli
- Uniprot:
- Q8WWA0
Description
| Product Name: | Human Omentin Recombinant Protein |
| Product Code: | RPPB0814 |
| Size: | 10µg |
| Species: | Human |
| Target: | Omentin |
| Synonyms: | Intelectin-1, HL1, LFR, HL-1, INTL, ITLN, hIntL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Each mg of lyophilized powder contains 20mM Tris & 50mM NaCl pH-8.0. |
| Solubility: | It is recommended to reconstitute the lyophilized Omentin His Tag in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Intelectin His Tag although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Intelectin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASTDEANT YFKEWTCSSS PSLPRSCKEI KDECPSAFDG LYFLRTENGV IYQTFCDMTS GGGGWTLVAS VHENDMRGKC TVGDRWSSQQ GSKAVYPEGD GNWANYNTFG SAEAATSDDY KNPGYYDIQA KDLGIWHVPN KSPMQHWRNS SLLRYRTDTG FLQTLGHNLF GIYQKYPVKY GEGKCWTDNG PVIPVVYDFG DAQKTASYYS PYGQREFTAG FVQFRVFNNE RAANALCAGM RVTGCNTEHH CIGGGGYFPE ASPQQCGDFS GFDWSGYGTH VGYS |
Omentin is a recently recognized gene highly localized to the mental tissue (visceral adipose tissue). Omentin is present in the stromal vascular cells in the adipose tissue rather than in the adipocytes. Omentin is predominantly expressed in the visceral adipose tissue than the subcutaneous tissue, with the omentin mRNA being 150 times higher in the visceral adipose tissue. Omentin has also been detected in human blood using western blot analysis, and seems to increase insulin-stimulated glucose uptake in 3T3-L1 adipocytes in mice. Omentin seems to increase Akt phosphorylation irrespective of insulin presence. Its role in glucose metabolism and obesity remains to be described; an insulin-sensitizing action is possible.Differences in Omentin expression has been noted in adipose tissue from normals and patients with inflammatory bowel disease although its significance is unknown.
Omentin Human Recombinant is produced in E.Coli by recombinant DNA technology is a single, polypeptide chain containing 294 amino acids and having a molecular mass of 32.7 kDa. Recombinant Human Omentin contains His tag fused at N-Terminus.Intelectin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ITLN1: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: brush border membrane; receptor complex; lipid raft Molecular Function:carbohydrate binding Biological Process: positive regulation of glucose import; response to nematode; positive regulation of protein amino acid phosphorylation |
| UniProt Code: | Q8WWA0 |
| NCBI GenInfo Identifier: | 55976553 |
| NCBI Gene ID: | 55600 |
| NCBI Accession: | Q8WWA0.1 |
| UniProt Secondary Accession: | Q8WWA0,Q5IWS4, Q5VYI4, Q6YDJ3, Q9NP67, |
| UniProt Related Accession: | Q8WWA0 |
| Molecular Weight: | 313 |
| NCBI Full Name: | Intelectin-1 |
| NCBI Synonym Full Names: | intelectin 1 (galactofuranose binding) |
| NCBI Official Symbol: | ITLN1 |
| NCBI Official Synonym Symbols: | HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin |
| NCBI Protein Information: | intelectin-1; ITLN-1; endothelial lectin HL-1; galactofuranose-binding lectin; intestinal lactoferrin receptor |
| UniProt Protein Name: | Intelectin-1 |
| UniProt Synonym Protein Names: | Endothelial lectin HL-1; Galactofuranose-binding lectin; Intestinal lactoferrin receptor; Omentin |
| Protein Family: | Intelectin |
| UniProt Gene Name: | ITLN1 |
| UniProt Entry Name: | ITLN1_HUMAN |
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