Human OLFM1 Recombinant Protein (RPPB4153)

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SKU:
RPPB4153
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
OLFM1
Synonyms:
olfactomedin 1
Synonyms:
NOE1
Synonyms:
NOELIN1
Synonyms:
OlfA
Source:
Escherichia Coli
Uniprot:
Q99784
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Description

Product Name:Human OLFM1 Recombinant Protein
Product Code:RPPB4153
Size:10µg
Species:Human
Target:OLFM1
Synonyms:olfactomedin 1, NOE1, NOELIN1, OlfA, Noelin, Neuronal olfactomedin-related ER localized protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:OLFM1 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 7.5), 0.2M NaCl, 50% glycerol and 5mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLPTNPEE SWQVYSSAQD SEGRCICTVV APQQTMCSRD ARTKQLRQLL EKVQNMSQSI EVLDRRTQRD LQYVEKMENQ MKGLESKFKQ VEESHKQHLA RQFKG

Olfactomedin 1 (OLFM1), also known as noelin, shares expansive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. OLFM1 plays a vital role in regulating the production of neural crest cells by the neural tube.

OLFM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids (34-135 a.a.) and having a molecular mass of 14.3kDa.OLFM1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:OLFM1: Seems to play an important role in regulating the production of neural crest cells by the neural tube. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation; Cell adhesion

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: extracellular space; synapse; cell junction

Molecular Function:protein binding; beta-amyloid binding

Biological Process: nervous system development; protein oligomerization

NCBI Summary:This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q99784
NCBI GenInfo Identifier:206729935
NCBI Gene ID:10439
NCBI Accession:Q99784.4
UniProt Secondary Accession:Q99784,Q53XZ8, Q6IMJ4, Q6IMJ5, Q8N8R0, Q969S7, Q99452
UniProt Related Accession:Q99784
Molecular Weight:485
NCBI Full Name:Noelin
NCBI Synonym Full Names:olfactomedin 1
NCBI Official Symbol:OLFM1  
NCBI Official Synonym Symbols:AMY; NOE1; OlfA; NOELIN1  
NCBI Protein Information:noelin; pancortin 1; olfactomedin-1; neuroblastoma protein; olfactomedin related ER localized protein; neuronal olfactomedin-related ER localized protein
UniProt Protein Name:Noelin
UniProt Synonym Protein Names:Neuronal olfactomedin-related ER localized protein; Olfactomedin-1
Protein Family:Noelin
UniProt Gene Name:OLFM1  
UniProt Entry Name:NOE1_HUMAN
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