Human NUTF2 Recombinant Protein (RPPB4144)
- SKU:
- RPPB4144
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- NUTF2
- Synonyms:
- Nuclear transport factor 2
- NTF-2
- Placental protein 15
- PP15
- Source:
- Escherichia Coli
- Uniprot:
- P61970
Description
| Product Name: | Human NUTF2 Recombinant Protein |
| Product Code: | RPPB4144 |
| Size: | 25µg |
| Species: | Human |
| Target: | NUTF2 |
| Synonyms: | Nuclear transport factor 2, NTF-2, Placental protein 15, PP15, NUTF2, NTF2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NUTF2 Human solution containing 20mM Tris HCL pH-8, & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH QMFLLKNIND AWVCTNDMFR LALHNFG |
NUTF2 assists in protein transport into the nucleus and interacts with the nucleoporin p62 and with Ran. NUTF2 plays a role at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. NUTF2 is part of a multicomponent system of cytosolic factors that come together at the pore complex during nuclear import.
NUTF2 Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 16.6 kDa. The NUTF2 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NUTF2: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. Homodimer. |
| UniProt Protein Details: | Protein type:Nuclear import Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cytosol; nuclear outer membrane; nuclear pore Molecular Function:protein binding; Ran GTPase binding; transporter activity Biological Process: positive regulation of protein import into nucleus; protein export from nucleus; protein import into nucleus, translocation |
| NCBI Summary: | This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016] |
| UniProt Code: | P61970 |
| NCBI GenInfo Identifier: | 48429030 |
| NCBI Gene ID: | 10204 |
| NCBI Accession: | P61970.1 |
| UniProt Secondary Accession: | P61970,P13662, Q6IB67, B2R4G7, |
| UniProt Related Accession: | P61970 |
| Molecular Weight: | 14,478 Da |
| NCBI Full Name: | Nuclear transport factor 2 |
| NCBI Synonym Full Names: | nuclear transport factor 2 |
| NCBI Official Symbol: | NUTF2 |
| NCBI Official Synonym Symbols: | NTF2; PP15; NTF-2 |
| NCBI Protein Information: | nuclear transport factor 2 |
| UniProt Protein Name: | Nuclear transport factor 2 |
| UniProt Synonym Protein Names: | Placental protein 15; PP15 |
| UniProt Gene Name: | NUTF2 |
| UniProt Entry Name: | NTF2_HUMAN |
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