Human NUP62 Recombinant Protein (RPPB4141)

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SKU:
RPPB4141
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NUP62
Synonyms:
Nuclear pore glycoprotein p62
Synonyms:
62 kDa nucleoporin
Synonyms:
Nucleoporin Nup62
Synonyms:
NUP62
Source:
Sf9 Insect cells
Uniprot:
P37198
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Description

Product Name:Human NUP62 Recombinant Protein
Product Code:RPPB4141
Size:20µg
Species:Human
Target:NUP62
Synonyms:Nuclear pore glycoprotein p62, 62 kDa nucleoporin, Nucleoporin Nup62, NUP62, p62, IBSN, SNDI.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:NUP62 is supplied in 20mM HEPES buffer pH-8, 200mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 91% as determined by SDS-PAGE.

Nucleopurin 62kDa (NUP62) belongs to the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. Nucleoporins are the principal components of the nuclear pore complex in eukaryotic cells. This complex is a colossal structure which extends across the nuclear envelope, forming an entryway that regulates the stream of macromolecules between the nucleus and the cytoplasm. NUP62 associates with the importin alpha/beta complex that is involved in the import of proteins containing nuclear localization signals. Defects in the NUP62 are the cause of SNDI (infantile striatonigral degeneration), aka infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration.

NUP62 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 66 kDa.NUP62 is expressed with a -10x His tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:NUP62: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI); also known as infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy and mental retardation. Belongs to the nucleoporin NSP1/NUP62 family.
UniProt Protein Details:

Protein type:Nucleoporin; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: pore complex; spindle pole; nucleocytoplasmic shuttling complex; nuclear membrane; intracellular membrane-bound organelle; cytoplasm; nuclear envelope; nuclear pore; ribonucleoprotein complex

Molecular Function:ubiquitin binding; protein binding; receptor signaling complex scaffold activity; structural constituent of nuclear pore; PTB domain binding; chromatin binding; SH2 domain binding; thyroid hormone receptor binding; nucleocytoplasmic transporter activity

Biological Process: cell death; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; mRNA transport; viral reproduction; hormone-mediated signaling; positive regulation of transcription, DNA-dependent; mitotic nuclear envelope disassembly; regulation of signal transduction; nucleocytoplasmic transport; pathogenesis; viral infectious cycle; glucose transport; negative regulation of cell proliferation; protein transport; cell surface receptor linked signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; negative regulation of programmed cell death; negative regulation of Ras protein signal transduction; viral transcription; transmembrane transport; regulation of Ras protein signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; cell aging; hexose transport; carbohydrate metabolic process; gene expression; mitotic cell cycle; negative regulation of apoptosis

Disease: Striatonigral Degeneration, Infantile

NCBI Summary:The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
UniProt Code:P37198
NCBI GenInfo Identifier:134047855
NCBI Gene ID:23636
NCBI Accession:P37198.3
UniProt Related Accession:P37198
Molecular Weight:
NCBI Full Name:Nuclear pore glycoprotein p62
NCBI Synonym Full Names:nucleoporin 62
NCBI Official Symbol:NUP62  
NCBI Official Synonym Symbols:p62; IBSN; SNDI  
NCBI Protein Information:nuclear pore glycoprotein p62
UniProt Protein Name:Nuclear pore glycoprotein p62
UniProt Synonym Protein Names:62 kDa nucleoporin; Nucleoporin Nup62
Protein Family:Nuclear pore glycoprotein
UniProt Gene Name:NUP62  
UniProt Entry Name:NUP62_HUMAN
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