Human NUCB2 Recombinant Protein (RPPB4135)
- SKU:
- RPPB4135
- Product type:
- Recombinant Protein
- Size:
- 100ug
- Species:
- Human
- Target:
- NUCB2
- Synonyms:
- Nucleobindin-2
- DNA-binding protein NEFA
- Gastric cancer antigen Zg4
- NUCB2
- Source:
- Escherichia Coli
- Uniprot:
- P80303
Description
| Product Name: | Human NUCB2 Recombinant Protein |
| Product Code: | RPPB4135 |
| Size: | 100µg |
| Species: | Human |
| Target: | NUCB2 |
| Synonyms: | Nucleobindin-2, DNA-binding protein NEFA, Gastric cancer antigen Zg4, NUCB2, NEFA, Nesfatin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The NUCB2 protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized NUCB2 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized NUCB2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NUCB2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | VPIDIDKTKV QNIHPVESAK IEPPDTGLYY DEYLKQVIDV LETDKHFREK LQKADIEEIK SGRLSKELDL VSHHVRTKLD EL |
Nucleobindin-2 (also known as NUCB2 or Nesfatin) is a EF-hand calcium-binding protein. Nucleobindin-2 takes part in calcium homeostasis and is a multifunctional protein that interacts with Ca(2+) nucleic acids & various regulatory proteins in different signaling pathways. NUCB2 (Nesfatin) is localized in neuronal perikarya and dendrites of mouse brain.
The Recombinant Human NUCB2 (Nesfatin) produced in E.coli has a molecular mass of 9.7kDa containing 82 amino acid residues of the human NUCB2.
| UniProt Protein Function: | NUCB2: Calcium-binding protein. May have a role in calcium homeostasis. Belongs to the nucleobindin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; ER-Golgi intermediate compartment; plasma membrane; nuclear envelope; cytosol Molecular Function:protein binding; DNA binding; calcium ion binding |
| NCBI Summary: | This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P80303 |
| NCBI GenInfo Identifier: | 224471846 |
| NCBI Gene ID: | 4925 |
| NCBI Accession: | P80303.2 |
| UniProt Secondary Accession: | P80303,Q8NFT5, A8K642, D3DQX5, |
| UniProt Related Accession: | P80303 |
| Molecular Weight: | 50,201 Da |
| NCBI Full Name: | Nucleobindin-2 |
| NCBI Synonym Full Names: | nucleobindin 2 |
| NCBI Official Symbol: | NUCB2 |
| NCBI Official Synonym Symbols: | NEFA; HEL-S-109 |
| NCBI Protein Information: | nucleobindin-2; nesfatin 1; nesfatin-1; prepronefastin; prepronesfatin; nucleobinding 2; DNA-binding protein NEFA; gastric cancer antigen Zg4; epididymis secretory protein Li 109 |
| UniProt Protein Name: | Nucleobindin-2 |
| UniProt Synonym Protein Names: | DNA-binding protein NEFA; Gastric cancer antigen Zg4; PrepronesfatinCleaved into the following chain:Nesfatin-1 |
| Protein Family: | Nucleobindin |
| UniProt Gene Name: | NUCB2 |
| UniProt Entry Name: | NUCB2_HUMAN |
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