Human NTS Recombinant Protein (RPPB4131)

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SKU:
RPPB4131
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NTS
Synonyms:
NTS
Synonyms:
Neurotensin
Synonyms:
NT/N
Synonyms:
NMN-125
Source:
Escherichia Coli
Uniprot:
P30990
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Description

Product Name:Human NTS Recombinant Protein
Product Code:RPPB4131
Size:20µg
Species:Human
Target:NTS
Synonyms:NTS, Neurotensin, NT/N, NMN-125, NTS1, NN, Neurotensin/Neuromedin N, NT.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NTS protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSDSEE EMKALEADFL TNMHTSKISK AHVPSWKMTL LNVCSLVNNL NSPAEETGEV HEEELVARRK LPTALDGFSL EAMLTIYQLH KICHSRAFQH WELIQEDILD TGNDKNGKEE VIKRKIPYIL KRQLYENKPR RPYILKRDSY YY

Neurotensin (NTS) is a common precursor for 2 peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is generally distributed throughout the central nervous system, and may serve as a neurotransmitter or a neuromodulator. NTS is involved in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may initiate the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may embody more stable peptides which are also biologically active.

NTS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 172 amino acids (24-170 a.a.) and having a molecular mass of 19.9kDa.NTS is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NTS: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Belongs to the neurotensin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.31

Cellular Component: extracellular region; nerve terminal

Molecular Function:neuropeptide hormone activity

NCBI Summary:This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
UniProt Code:P30990
NCBI GenInfo Identifier:2828196
NCBI Gene ID:4922
NCBI Accession:P30990.2
UniProt Related Accession:P30990
Molecular Weight:20kDa
NCBI Full Name:Neurotensin/neuromedin N
NCBI Synonym Full Names:neurotensin
NCBI Official Symbol:NTS  
NCBI Official Synonym Symbols:NN; NT; NT/N; NTS1; NMN-125  
NCBI Protein Information:neurotensin/neuromedin N
UniProt Protein Name:Neurotensin/neuromedin N
UniProt Synonym Protein Names:Large neuromedin NAlternative name(s):NmN-125
Protein Family:Neurotensin
UniProt Gene Name:NTS  
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