Human NTRK2 Recombinant Protein (RPPB0811)
- SKU:
- RPPB0811
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- NTRK2
- Synonyms:
- GP145-TrkB
- trk-B
- TRKB
- NTRK2
- Source:
- Sf9 Insect cells
- Uniprot:
- Q16620
Description
| Product Name: | Human NTRK2 Recombinant Protein |
| Product Code: | RPPB0811 |
| Size: | 10µg |
| Species: | Human |
| Target: | NTRK2 |
| Synonyms: | GP145-TrkB, trk-B, TRKB, NTRK2 |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NTRK2 solution (0. 5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREHL EHHHHHH |
Neurotrophic Receptor Tyrosine Kinase 2, also referred to NTRK2, is a tyrosine-protein kinase receptor which takes part in the development & the maturation of the central and the peripheral nervous systems through regulation of neuron survival, migration, proliferation, differentiation and synapse formation & plasticity. NTRK2 acts in learning and memory by regulating both short term synaptic function and long-term potentiation. The substrates that are known for the TRK family receptors are: SHC1, PI-3 kinase and PLC-gamma-1.
NTRK2 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 407 amino acids (32-430a.a) and having a molecular mass of 45.2kDa.NTRK2 is fused to an 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family Chromosomal Location of Human Ortholog: 9q22.1 Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; presynaptic active zone; endosome membrane; receptor complex Molecular Function:brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; neuron migration; regulation of dendrite development; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; inflammatory response; vasculogenesis; neuromuscular junction development; central nervous system neuron development; aging; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Obesity, Hyperphagia, And Developmental Delay |
| NCBI Summary: | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | Q16620 |
| NCBI GenInfo Identifier: | 2497560 |
| NCBI Gene ID: | 4915 |
| NCBI Accession: | Q16620.1 |
| UniProt Secondary Accession: | Q16620,Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7, B1ANZ4 B4DFV9, |
| UniProt Related Accession: | Q16620 |
| Molecular Weight: | 822 |
| NCBI Full Name: | BDNF/NT-3 growth factors receptor |
| NCBI Synonym Full Names: | neurotrophic tyrosine kinase, receptor, type 2 |
| NCBI Official Symbol: | NTRK2 |
| NCBI Official Synonym Symbols: | TRKB; trk-B; GP145-TrkB |
| NCBI Protein Information: | BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B |
| UniProt Protein Name: | BDNF/NT-3 growth factors receptor |
| UniProt Synonym Protein Names: | GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B |
| Protein Family: | BDNF/NT-3 growth factors receptor |
| UniProt Gene Name: | NTRK2 |
| UniProt Entry Name: | NTRK2_HUMAN |
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