Human NRN1 Recombinant Protein (RPPB0795)

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SKU:
RPPB0795
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
NRN1
Synonyms:
Neuritin 1
Synonyms:
NRN1
Synonyms:
NRN
Synonyms:
dJ380B82
Source:
Escherichia Coli
Uniprot:
Q9NPD7
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Description

Product Name:Human NRN1 Recombinant Protein
Product Code:RPPB0795
Size:10µg
Species:Human
Target:NRN1
Synonyms:Neuritin 1, NRN1, NRN, dJ380B8.2, Neuritin.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:NRN1 was filtered (0.4 µm) and lyophilized in 20mM Tris buffer, 50mM NaCl, pH 8.0, 1% (w/v) Sucrose and 4% (w/v) Mannitol.
Solubility:It is recommended to add 200µl of deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. NRN1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASAGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGNG

Neuritin (NRN1) is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3 and other neural stimulators. NRN1 is expressed principally in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. NRN1 functions as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation.

Neuritin-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Ala28-Gly116) containing 99 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 11.02kDa.

UniProt Protein Function:NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: plasma membrane; synapse; cell junction

Biological Process: nervous system development

NCBI Summary:This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9NPD7
NCBI GenInfo Identifier:74752881
NCBI Gene ID:51299
NCBI Accession:Q9NPD7.1
UniProt Secondary Accession:Q9NPD7,Q7Z4Y1, B2RA93,
UniProt Related Accession:Q9NPD7
Molecular Weight:15,333 Da
NCBI Full Name:Neuritin
NCBI Synonym Full Names:neuritin 1
NCBI Official Symbol:NRN1  
NCBI Official Synonym Symbols:NRN; dJ380B8.2  
NCBI Protein Information:neuritin
UniProt Protein Name:Neuritin
Protein Family:Neuritin
UniProt Gene Name:NRN1  
UniProt Entry Name:NRN1_HUMAN
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