Human NPC1 Recombinant Protein (RPES2958)
- SKU:
- RPES2958
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Human
Frequently bought together:
Description
system_update_alt데이터시트
Human NPC1 Recombinant Protein
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
| Product Name: | Human NPC1 Recombinant Protein (RPES2958) |
| Product Code: | RPES2958 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | NPC |
| Accession: | NP_000262.2 |
| Sequence: | Arg372-Phe622 |
| Fusion tag: | N-His & FLAG |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human NPC1 (NP_000262.2) (Arg372-Phe622) was expressed with a N-terminal polyhistide-tagged FLAG tag at the N-terminus (his-FLAG). |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 32 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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