Human NOV Recombinant Protein (RPPB0807)
- SKU:
- RPPB0807
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- NOV
- Synonyms:
- Protein NOV homolog
- NovH
- CCN family member 3
- nsulin-like growth factor-binding protein 9
- Source:
- HEK293 Cells
- Uniprot:
- P48745
Description
| Product Name: | Human NOV Recombinant Protein |
| Product Code: | RPPB0807 |
| Size: | 10µg |
| Species: | Human |
| Target: | NOV |
| Synonyms: | Protein NOV homolog, NovH, CCN family member 3, nsulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephroblastoma-overexpressed gene protein homolog, NOV, CCN3, IGFBP9, NOVH. |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | NOV filtered (0.4 µm) and lyophilized from 0.5mg/ml in PBS and 5 % (w/v) trehalose. |
| Solubility: | It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. NOV is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QRCPPQCPGR CPATPPTCAP GVRAVLDGCS CCLVCARQRG ESCSDLEPCD ESSGLYCDRS ADPSNQTGIC TAVEGDNCVF DGVIYRSGEK FQPSCKFQCT CRDGQIGCVP RCQLDVLLPE PNCPAPRKVE VPGECCEKWI CGPDEEDSLG GLTLAAYRPE ATLGVEVSDS SVNCIEQTTE WTACSKSCGM GFSTRVTNRN RQCEMLKQTR LCMVRPCEQE PEQPTDKKGK KCLRTKKSLK AIHLQFKNCT SLHTYKPRFC GVCSDGRCCT PHNTKTIQAE FQCSPGQIVK KPVMVIGTCT CHTNCPKNNE AFLQELELKT TRGKMHHHHH H |
Nephroblastoma Overexpressed (NOV) which is encoded by the NOV gene is a part of the CCN (CTGF/CYR61/NOV) family. NOV takes part in reducing tumorgenicity and proliferation of certain cancer cell lines. NOV interacts with numerous proteins and is involved in both internal and external cell signaling. NOV is expressed in particular tumors, including Wilm’s tumor and most nephroblastomas and is also exerts proangiogenic activities.
NOV Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a.a 33-357) containing 331 amino acids including a 6 a.a C-terminal His tag. The total molecular mass is 36.5kDa (calculated).
| UniProt Protein Function: | NOV: Immediate-early protein likely to play a role in cell growth regulation. Belongs to the CCN family. Expression is down-regulated by WT1. Interacts with FBLN1. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8q24.1 Cellular Component: proteinaceous extracellular matrix; cell soma; intracellular membrane-bound organelle; axon; dendrite Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding; growth factor activity Biological Process: cell-cell signaling; regulation of gene expression; regulation of cell growth; cell adhesion; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P48745 |
| NCBI GenInfo Identifier: | 1352515 |
| NCBI Gene ID: | 4856 |
| NCBI Accession: | P48745.1 |
| UniProt Secondary Accession: | P48745,Q6I9S3, Q96BY5, Q9UDE4, B2R5X7, |
| UniProt Related Accession: | P48745 |
| Molecular Weight: | 39,162 Da |
| NCBI Full Name: | Protein NOV homolog |
| NCBI Synonym Full Names: | nephroblastoma overexpressed |
| NCBI Official Symbol: | NOV |
| NCBI Official Synonym Symbols: | CCN3; NOVh; IBP-9; IGFBP9; IGFBP-9 |
| NCBI Protein Information: | protein NOV homolog; CCN family member 3; IGF-binding protein 9; insulin-like growth factor-binding protein 9; nephroblastoma-overexpressed gene protein homolog |
| UniProt Protein Name: | Protein NOV homolog |
| UniProt Synonym Protein Names: | CCN family member 3; Insulin-like growth factor-binding protein 9; IBP-9; IGF-binding protein 9; IGFBP-9; Nephroblastoma-overexpressed gene protein homolog |
| Protein Family: | Protein |
| UniProt Gene Name: | NOV |
| UniProt Entry Name: | NOV_HUMAN |
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