Human NMT2 Recombinant Protein (RPPB2029)
- SKU:
- RPPB2029
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- NMT2
- Synonyms:
- Glycylpeptide N-tetradecanoyltransferase 2
- Myristoyl-CoA:protein N-myristoyltransferase 2
- NMT 2
- Peptide N-myristoyltransferase 2
- Source:
- Escherichia Coli
- Uniprot:
- O60551
Description
| Product Name: | Human NMT2 Recombinant Protein |
| Product Code: | RPPB2029 |
| Size: | 20µg |
| Species: | Human |
| Target: | NMT2 |
| Synonyms: | Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Peptide N-myristoyltransferase 2, Type II N-myristoyltransferase, NMT2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NMT2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH RSLNPKKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ |
Glycylpeptide N-tetradecan-oyltransferases 2 (NMT2) is a cytoplasmic protein which is a member of the NMT family of proteins. The proteins in the NMT family catalyze the addition of a myristoyl group to the N-terminal glycine residue of eukaryotic, fungal and viral proteins. These proteins are mostly detected in the heart, gut, kidney, liver and placenta. NMT catalyzes the reaction of N-terminal myristoylation of various signaling proteins. NMT transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. There are several distinct NMTs which vary in the molecular weight and /or subcellular distribution.
NMT2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 518 amino acids (1-498 a.a.) and having a molecular mass of 59.1kDa. The NMT2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NMT2: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Belongs to the NMT family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.97; Transferase Chromosomal Location of Human Ortholog: 10p13 Cellular Component: cytoplasm; cytosol; extrinsic to membrane; Golgi apparatus; plasma membrane Molecular Function:glycylpeptide N-tetradecanoyltransferase activity Biological Process: N-terminal peptidyl-glycine N-myristoylation; regulation of rhodopsin mediated signaling |
| NCBI Summary: | This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | O60551 |
| NCBI GenInfo Identifier: | 6225770 |
| NCBI Gene ID: | 9397 |
| NCBI Accession: | O60551.1 |
| UniProt Secondary Accession: | O60551,Q53Y38, Q5VUC8, Q9BRB4, B0YJ49, |
| UniProt Related Accession: | O60551 |
| Molecular Weight: | 57kDa |
| NCBI Full Name: | Glycylpeptide N-tetradecanoyltransferase 2 |
| NCBI Synonym Full Names: | N-myristoyltransferase 2 |
| NCBI Official Symbol: | NMT2 |
| NCBI Protein Information: | glycylpeptide N-tetradecanoyltransferase 2 |
| UniProt Protein Name: | Glycylpeptide N-tetradecanoyltransferase 2 |
| UniProt Synonym Protein Names: | Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Peptide N-myristoyltransferase 2; Type II N-myristoyltransferase |
| Protein Family: | Glycylpeptide N-tetradecanoyltransferase |
| UniProt Gene Name: | NMT2 |
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