Human NKIRAS1 Recombinant Protein (RPPB4099)

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SKU:
RPPB4099
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
NKIRAS1
Synonyms:
NF-kappa-B inhibitor-interacting Ras-like protein 1
Synonyms:
I-kappa-B-interacting Ras-like protein 1
Synonyms:
Kappa B-Ras protein 1
Synonyms:
KappaB-Ras1
Source:
Escherichia Coli
Uniprot:
Q9NYS0
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Description

Product Name:Human NKIRAS1 Recombinant Protein
Product Code:RPPB4099
Size:5µg
Species:Human
Target:NKIRAS1
Synonyms:NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1, KappaB-Ras1, NKIRAS1, KBRAS1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NKIRAS1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD RGVKEQLHLY DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP GRKNKGNSNS EN

NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1) is a member of the small GTPase superfamily. NKIRAS1 is an unusual Ras-like protein which acts as a potent regulator of NF-kappa-B activity by thwarting the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, describing why NFKBIB is more resistant to degradation. NKIRAS1 functions by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

NKIRAS1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-192 a.a) and having a molecular mass of 23.8kDa (Molecular weight on SDS-PAGE will appear higher).NKIRAS1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
UniProt Protein Details:

Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 3p24.2

UniProt Code:Q9NYS0
NCBI GenInfo Identifier:74753075
NCBI Gene ID:28512
NCBI Accession:Q9NYS0.1
UniProt Secondary Accession:Q9NYS0,Q96K18,
UniProt Related Accession:Q9NYS0
Molecular Weight:21,643 Da
NCBI Full Name:NF-kappa-B inhibitor-interacting Ras-like protein 1
NCBI Synonym Full Names:NFKB inhibitor interacting Ras like 1
NCBI Official Symbol:NKIRAS1  
NCBI Official Synonym Symbols:KBRAS1; kappaB-Ras1  
NCBI Protein Information:NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Protein Name:NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Synonym Protein Names:I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1
Protein Family:NF-kappa-B inhibitor-interacting Ras-like protein
UniProt Gene Name:NKIRAS1  
UniProt Entry Name:KBRS1_HUMAN
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