Human NHLH1 Recombinant Protein (RPPB4093)

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SKU:
RPPB4093
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
NHLH1
Synonyms:
Nescient Helix Loop Helix 1
Synonyms:
Class A Basic Helix-Loop-Helix Protein 35
Synonyms:
Helix-Loop-Helix Protein 1
Synonyms:
BHLHA35
Source:
Escherichia Coli
Uniprot:
Q02575
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Description

Product Name:Human NHLH1 Recombinant Protein
Product Code:RPPB4093
Size:5µg
Species:Human
Target:NHLH1
Synonyms:Nescient Helix Loop Helix 1, Class A Basic Helix-Loop-Helix Protein 35, Helix-Loop-Helix Protein 1, BHLHA35, NSCL1, HEN1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NHLH1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM DTT and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMMLNSDT MELDLPPTHS ETESGFSDCG GGAGPDGAGP GGPGGGQARG PEPGEPGRKD LQHLSREERR RRRRATAKYR TAHATRERIR VEAFNLAFAE LRKLLPTLPP DKKLSKIEIL RLAICYISYL NHVLDV

HLH (helix-loop-helix) proteins are a putative transcription factors family. Several HLH proteins take part in growth and development of an extensive range of tissues and species. NHLH1 functions as a DNA-binding protein and has a role in the regulation of cell-type determination in the developing nervous system.

NHLH1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-133) and having a molecular mass of 17.0kDa.NHLH1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NHLH1: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleus

Biological Process: central nervous system development; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
UniProt Code:Q02575
NCBI GenInfo Identifier:399885
NCBI Gene ID:4807
NCBI Accession:Q02575.1
UniProt Related Accession:Q02575
Molecular Weight:14,618 Da
NCBI Full Name:Helix-loop-helix protein 1
NCBI Synonym Full Names:nescient helix-loop-helix 1
NCBI Official Symbol:NHLH1  
NCBI Official Synonym Symbols:HEN1; NSCL; NSCL1; bHLHa35  
NCBI Protein Information:helix-loop-helix protein 1
UniProt Protein Name:Helix-loop-helix protein 1
UniProt Synonym Protein Names:Class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1
Protein Family:Helix-loop-helix protein
UniProt Gene Name:NHLH1  
UniProt Entry Name:HEN1_HUMAN
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