Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development; neurotransmission; and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems; and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder; with etiology likely due to epistasis.
Product Name:
Human Neuregulin/NRG1-Beta 1 Recombinant Protein (RPES0762)
1. Measured by its binding ability in a functional ELISA.2. Immobilized Rhesus ErbB3 at 2 µg/mL (100 ?l/well) can bind human NRG1 (isoform Beta1); The EC50 of human NRG1 (isoform Beta1) is 0.58 µg/mL.3. Immobilized human ErbB3 at 2 µg/mL (100 ?l/well) can bind human NRG1 (isoform Beta1); The EC50 of human NRG1 (isoform Beta1) is 0.43 µg/mL.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the EGF-like domain (Thr 176-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus.
Purity:
> 86 % as determined by reducing SDS-PAGE.
Mol Mass:
36.7 kDa
AP Mol Mass:
38 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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