Human NEK7 Recombinant Protein (RPPB2589)
- SKU:
- RPPB2589
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- NEK7
- Synonyms:
- NIMA (never in mitosis gene a)-related kinase 7
- Serine/threonine-protein kinase Nek7
- Source:
- Escherichia Coli
- Uniprot:
- Q8TDX7
Frequently bought together:
Description
| Product Name: | Human NEK7 Recombinant Protein |
| Product Code: | RPPB2589 |
| Size: | 20µg |
| Species: | Human |
| Target: | NEK7 |
| Synonyms: | NIMA (never in mitosis gene a)-related kinase 7, Serine/threonine-protein kinase Nek7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NEK7 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) , 0.15M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMDEQSQ GMQGPPVPQF QPQKALRPDM GYNTLANFRI EKKIGRGQFS EVYRAACLLD GVPVALKKVQ IFDLMDAKAR ADCIKEIDLL KQLNHPNVIK YYASFIEDNE LNIVLELADA GDLSRMIKHF KKQKRLIPER TVWKYFVQLC SALEHMHSRR VMHRDIKPAN VFITATGVVK LGDLGLGRFF SSKTTAAHSL VGTPYYMSPE RIHENGYNFK SDIWSLGCLL YEMAALQSPF YGDKMNLYSL CKKIEQCDYP PLPSDHYSEE LRQLVNMCIN PDPEKRPDVT YVYDVAKRMH ACTASS |
NEK7, protein kinase, has a vital role in mitotic cell cycle progression. It is essential for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. NEK7 is greatly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen.
NEK7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 326 amino acids (1-302 a.a) and having a molecular mass of 37kDa.NEK7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NEK7: a protein kinase of the NEK family. Phosphorylates and activates p70S6 kinase.Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; NEK familyChromosomal Location of Human Ortholog: 1q31.3Cellular Component: cytoplasm; microtubule; microtubule organizing center; nucleoplasm; spindle poleMolecular Function: ATP binding; metal ion binding; protein serine/threonine kinase activityBiological Process: cytokinesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; regulation of mitotic cell cycle; spindle assembly |
| UniProt Protein Details: | |
| NCBI Summary: | NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q8TDX7 |
| NCBI GenInfo Identifier: | 37537965 |
| NCBI Gene ID: | 140609 |
| NCBI Accession: | Q8TDX7.1 |
| UniProt Secondary Accession: | Q8TDX7,A6NGT8 |
| UniProt Related Accession: | Q8TDX7 |
| Molecular Weight: | 13,402 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Nek7 |
| NCBI Synonym Full Names: | NIMA related kinase 7 |
| NCBI Official Symbol: | NEK7 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | serine/threonine-protein kinase Nek7 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek7 |
| UniProt Synonym Protein Names: | Never in mitosis A-related kinase 7; NimA-related protein kinase 7 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | NEK7 |
| UniProt Entry Name: | NEK7_HUMAN |
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