Human NECAP2 Recombinant Protein (RPPB4079)

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SKU:
RPPB4079
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NECAP2
Synonyms:
NECAP endocytosis-associated protein 2
Synonyms:
NECAP-2
Synonyms:
FLJ10420
Synonyms:
Adaptin ear-binding coat-associated protein 2
Source:
Escherichia Coli
Uniprot:
Q9NVZ3
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Description

Product Name:Human NECAP2 Recombinant Protein
Product Code:RPPB4079
Size:20µg
Species:Human
Target:NECAP2
Synonyms:NECAP endocytosis-associated protein 2, NECAP-2, FLJ10420, Adaptin ear-binding coat-associated protein 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NECAP2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEESGYESVL CVKPDVHVYR IPPRATNRGY RAAEWQLDQP SWSGRLRITA KGQMAYIKLE DRTSGELFAQ APVDQFPGTA VESVTDSSRY FVIRIEDGNG RRAFIGIGFG DRGDAFDFNV ALQDHFKWVK QQCEFAKQAQ NPDQGPKLDL GFKEGQTIKL NIANMKKKEG AAGNPRVRPA STGGLSLLPP PPGGKTSTLI PPPGEQLAVG GSLVQPAVAP SSGGAPVPWP QPNPATADIW GDFTKSTGST SSQTQPGTGW VQF

NECAP2 which is involved in endocytosis, is a vital protein paralogues for clathrin-mediated membrane trafficking which are enhanced in CCV layers.

NECAP2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 283 amino acids (1-263a.a.) and having a molecular mass of 30.5 kDa. NECAP2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NECAP2: Involved in endocytosis. Belongs to the NECAP family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: clathrin vesicle coat; plasma membrane; coated pit; intracellular

Biological Process: protein transport; endocytosis

NCBI Summary:This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
UniProt Code:Q9NVZ3
NCBI GenInfo Identifier:8922416
NCBI Gene ID:55707
NCBI Accession:NP_060560.1
UniProt Secondary Accession:Q9NVZ3,Q5VSU4, Q5VSU5, Q9H7L1, Q9H8L1, B4DY19, E9PGQ8
UniProt Related Accession:Q9NVZ3
Molecular Weight:25,267 Da
NCBI Full Name:adaptin ear-binding coat-associated protein 2 isoform 1
NCBI Synonym Full Names:NECAP endocytosis associated 2
NCBI Official Symbol:NECAP2  
NCBI Protein Information:adaptin ear-binding coat-associated protein 2; NECAP-2; NECAP endocytosis-associated protein 2; adaptin-ear-binding coat-associated protein 2
UniProt Protein Name:Adaptin ear-binding coat-associated protein 2
UniProt Synonym Protein Names:NECAP endocytosis-associated protein 2; NECAP-2
Protein Family:Adaptin ear-binding coat-associated protein
UniProt Gene Name:NECAP2  
UniProt Entry Name:NECP2_HUMAN
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