Human NDUFS3 Recombinant Protein (RPPB2012)
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주문- SKU:
- RPPB2012
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- NDUFS3
- Synonyms:
- CI-30
- Synonyms:
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3
- Synonyms:
- mitochondria
- Synonyms:
- Complex I-30kD
- Source:
- Escherichia Coli
- Uniprot:
- O75489
Description
| Product Name: | Human NDUFS3 Recombinant Protein |
| Product Code: | RPPB2012 |
| Size: | 5µg |
| Species: | Human |
| Target: | NDUFS3 |
| Synonyms: | CI-30, NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondria, Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NDUFS3 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MESAGADTRP TVRPRNDVAH KQLSAFGEYV AEILPKYVQQ VQVSCFNELE VCIHPDGVIP VLTFLRDHTN AQFKSLVDLT AVDVPTRQNR FEIVYNLLSL RFNSRIRVKT YTDELTPIES AVSVFKAANW YEREIWDMFG VFFANHPDLR RILTDYGFEG HPFRKDFPLS GYVELRYDDE VKRVVAEPVE LAQEFRKFDL NSPWEAFPVY RQPPESLKLE AGDKKPDAK |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (NDUFS3) is a member of the complex I 30 kDa subunit family. NDUFS3 is one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). This complex is the first enzyme complex in the electron transport chain of mitochondria. The iron-sulfur protein (IP) fraction of complex I consists of seven subunits. NDUFS3 gene mutations are linked with Leigh syndrome resulting from mitochondrial complex indefficiency.
Recombinant Human NDUFS3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 249amino acids (37-264 a.a.) and having a molecular mass of 28.7 kDa. NDUFS3 is fused to a 21 amino acid His Tag at N-terminus and purified by conventional chromatography techniques.
| UniProt Protein Function: | NDUFS3: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 30 kDa subunit family. |
| UniProt Protein Details: | Protein type:EC 1.6.5.3; Oxidoreductase; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 11p11.11 Cellular Component: mitochondrial matrix; mitochondrial membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleus Molecular Function:NADH dehydrogenase activity; protein binding Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; negative regulation of cell growth; substantia nigra development Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency |
| NCBI Summary: | This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009] |
| UniProt Code: | O75489 |
| NCBI GenInfo Identifier: | 6166589 |
| NCBI Gene ID: | 4722 |
| NCBI Accession: | O75489.1 |
| UniProt Secondary Accession: | O75489,Q9UNQ8, B2R9J1, B4DFM8, |
| UniProt Related Accession: | O75489 |
| Molecular Weight: | 14,679 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase core subunit S3 |
| NCBI Official Symbol: | NDUFS3 |
| NCBI Official Synonym Symbols: | CI-30 |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| UniProt Synonym Protein Names: | Complex I-30kD; CI-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit |
| UniProt Gene Name: | NDUFS3 |
| UniProt Entry Name: | NDUS3_HUMAN |
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