Human NDRG2 Recombinant Protein (RPPB4077)
- SKU:
- RPPB4077
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- NDRG2
- Synonyms:
- N-myc downstream-regulated gene 2 protein
- NDR1-related protein NDR2
- protein NDRG2
- NDRG family member 2
- Source:
- Escherichia Coli
- Uniprot:
- Q9UN36
Description
| Product Name: | Human NDRG2 Recombinant Protein |
| Product Code: | RPPB4077 |
| Size: | 20µg |
| Species: | Human |
| Target: | NDRG2 |
| Synonyms: | N-myc downstream-regulated gene 2 protein, NDR1-related protein NDR2, protein NDRG2, NDRG family member 2, cytoplasmic protein Ndr1, syld709613 protein, KIAA1248, SYLD. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NDRG2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAELQE VQITEEKPLL PGQTPEAAKT HSVETPYGSV TFTVYGTPKP KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS LDQLADMIPC VLQYLNFSTI IGVGVGAGAY ILARYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR RDLNFERGGD ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS QSSESGTLSS GPPGHTMEVS C |
NDRG2 belongs to the N-myc downregulated gene family that is a part of the alpha/beta hydrolase superfamily. NDRG2 takes part in dendritic and neuronal cell differentiation and outgrowth and is found in large quantities in heart, dendritic cells, brain, salivary gland and skeletal muscle and in small quantities in kidney and liver. In Alzheimer Disease (AD)-affected patients NDRG2 is found in brain lesions and is believed to be related to the progression of AD.
NDRG2 Human Recombinant produced in E. coli is a single polypeptide chain containing 381 amino acids (1-357) and having a molecular mass of 41.8 kDa.NDRG2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NDRG2: a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease |
| UniProt Protein Details: | Protein type:Tumor suppressor; Apoptosis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; cytosol Molecular Function:protein binding Biological Process: Wnt receptor signaling pathway; substantia nigra development; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation |
| NCBI Summary: | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UN36 |
| NCBI GenInfo Identifier: | 20141615 |
| NCBI Gene ID: | 57447 |
| NCBI Accession: | Q9UN36.2 |
| UniProt Secondary Accession: | Q9UN36,Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, B3KUE3 B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, |
| UniProt Related Accession: | Q9UN36 |
| Molecular Weight: | 371 |
| NCBI Full Name: | Protein NDRG2 |
| NCBI Synonym Full Names: | NDRG family member 2 |
| NCBI Official Symbol: | NDRG2 |
| NCBI Official Synonym Symbols: | SYLD |
| NCBI Protein Information: | protein NDRG2; syld709613 protein; cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein |
| UniProt Protein Name: | Protein NDRG2 |
| UniProt Synonym Protein Names: | N-myc downstream-regulated gene 2 protein; Protein Syld709613 |
| Protein Family: | Protein |
| UniProt Gene Name: | NDRG2 |
| UniProt Entry Name: | NDRG2_HUMAN |
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