Human NCR2 Recombinant Protein (RPPB4068)

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SKU:
RPPB4068
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NCR2
Synonyms:
Natural Cytotoxicity Triggering Receptor 2
Synonyms:
Lymphocyte Antigen 95 (Activating NK-Receptor
Synonyms:
NK-P44)
Synonyms:
Natural Killer Cell P44-Related Protein
Source:
Escherichia Coli
Uniprot:
O95944
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Description

Product Name:Human NCR2 Recombinant Protein
Product Code:RPPB4068
Size:20µg
Species:Human
Target:NCR2
Synonyms:Natural Cytotoxicity Triggering Receptor 2, Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44), Natural Killer Cell P44-Related Protein, NK Cell-Activating Receptor, Lymphocyte Antigen 95 Homolog, CD336 Antigen, NK-p44, LY95, dJ149M18.1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NCR2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSQAQSKAQV LQSVAGQTLT VRCQYPPTGS LYEKKGWCKE ASALVCIRLV TSSKPRTMAW TSRFTIWDDP DAGFFTVTMT DLREEDSGHY WCRIYRPSDN SVSKSVRFYL VVS

NCR2 is a member of the natural cytotoxicity receptor (NCR) family and holds 1 immunoglobulin-like (Ig-like) domain. NCR2 cooperates with TYROBP/DAP12 and is specifically expressed by activated NK cells and by in vitro cultured TCRg/d lymphoid cells. NCR2 is a cytotoxicity-activating receptor which induces the amplified efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

NCR2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (19-130) and having a molecular mass of 15.0 kDa. NCR2 is fused to a 21 amino acid His-tag at N-terminus.

UniProt Protein Function:NCR2: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: innate immune response; cellular defense response; signal transduction

UniProt Code:O95944
NCBI GenInfo Identifier:251757303
NCBI Gene ID:9436
NCBI Accession:O95944.2
UniProt Secondary Accession:O95944,Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2,
UniProt Related Accession:O95944
Molecular Weight:276
NCBI Full Name:Natural cytotoxicity triggering receptor 2
NCBI Synonym Full Names:natural cytotoxicity triggering receptor 2
NCBI Official Symbol:NCR2  
NCBI Official Synonym Symbols:LY95; CD336; NKP44; NK-p44; dJ149M18.1  
NCBI Protein Information:natural cytotoxicity triggering receptor 2; NK cell-activating receptor; NK cell activating receptor (NKp44); natural killer cell p44-related protein; lymphocyte antigen 95 (activating NK-receptor; NK-p44); lymphocyte antigen 95 homolog (activating NK-rec
UniProt Protein Name:Natural cytotoxicity triggering receptor 2
UniProt Synonym Protein Names:Lymphocyte antigen 95 homolog; NK cell-activating receptor; Natural killer cell p44-related protein; NK-p44; NKp44; CD_antigen: CD336
Protein Family:Natural cytotoxicity triggering receptor
UniProt Gene Name:NCR2  
UniProt Entry Name:NCTR2_HUMAN
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