Human NAPG Recombinant Protein (RPPB4237)
- SKU:
- RPPB4237
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- NAPG
- Synonyms:
- Gamma-soluble NSF attachment protein
- SNAP-gamma
- N-ethylmaleimide-sensitive factor attachment protein gamma
- NAPG
- Source:
- Escherichia Coli
- Uniprot:
- Q99747
Description
| Product Name: | Human NAPG Recombinant Protein |
| Product Code: | RPPB4237 |
| Size: | 20µg |
| Species: | Human |
| Target: | NAPG |
| Synonyms: | Gamma-soluble NSF attachment protein, SNAP-gamma, N-ethylmaleimide-sensitive factor attachment protein gamma, NAPG, SNAPG, GAMMASNAP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NAPG protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAAQKI NEGLEHLAKA EKYLKTGFLK WKPDYDSAAS EYGKAAVAFK NAKQFEQAKD ACLREAVAHE NNRALFHAAK AYEQAGMMLK EMQKLPEAVQ LIEKASMMYL ENGTPDTAAM ALERAGKLIE NVDPEKAVQL YQQTANVFEN EERLRQAVEL LGKASRLLVR GRRFDEAALS IQKEKNIYKE IENYPTCYKK TIAQVLVHLH RNDYVAAERC VRESYSIPGF NGSEDCAALE QLLEGYDQQD QDQVSDVCNS PLFKYMDNDY AKLGLSLVVP GGGIKKKSPA TPQAKPDGVT ATAADEEEDE YSGGLC |
Gamma-SNAP (NAPG) is a cytoplasmic protein which binds to a membrane receptor complex composed of VAMP, SNAP25 and syntaxin. NAPG mediates the membrane binding of NSF, which is crucial for membrane fusion reactions. NSF and SNAPs seem to be general components of the intracellular membrane fusion system, and their action at specific sites of fusion needs be controlled by SNAP receptors specific to the membranes being fused. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.
NAPG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.3kDa.NAPG is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SNAP-gamma: a cytoplasmic peripheral membrane protein that mediates platelet exocytosis and controls the membrane fusion events of this process. Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 18p11.22 Cellular Component: lysosomal membrane; mitochondrion; SNARE complex Molecular Function:protein binding; soluble NSF attachment protein activity; syntaxin binding Biological Process: intra-Golgi vesicle-mediated transport; intracellular protein transport |
| NCBI Summary: | This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008] |
| UniProt Code: | Q99747 |
| NCBI GenInfo Identifier: | 3024632 |
| NCBI Gene ID: | 8774 |
| NCBI Accession: | Q99747.1 |
| UniProt Secondary Accession: | Q99747,Q9BUV1, B4DFC9, |
| UniProt Related Accession: | Q99747 |
| Molecular Weight: | 25,662 Da |
| NCBI Full Name: | Gamma-soluble NSF attachment protein |
| NCBI Synonym Full Names: | NSF attachment protein gamma |
| NCBI Official Symbol: | NAPG |
| NCBI Official Synonym Symbols: | GAMMASNAP |
| NCBI Protein Information: | gamma-soluble NSF attachment protein |
| UniProt Protein Name: | Gamma-soluble NSF attachment protein |
| UniProt Synonym Protein Names: | N-ethylmaleimide-sensitive factor attachment protein gamma |
| Protein Family: | Ferredoxin-type protein |
| UniProt Gene Name: | NAPG |
| UniProt Entry Name: | SNAG_HUMAN |
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