Human N6AMT1 Recombinant Protein (RPPB1989)

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SKU:
RPPB1989
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
N6AMT1
Synonyms:
N-6 Adenine-Specific DNA Methyltransferase 1 (Putative)
Synonyms:
N(6)-Adenine-SpecificDNA Methyltransferase 1
Synonyms:
HemK Methyltransferase Family Member 2
Synonyms:
MHsaHemK2P
Source:
Escherichia Coli
Uniprot:
Q9Y5N5
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Description

Product Name:Human N6AMT1 Recombinant Protein
Product Code:RPPB1989
Size:10µg
Species:Human
Target:N6AMT1
Synonyms:N-6 Adenine-Specific DNA Methyltransferase 1 (Putative), N(6)-Adenine-SpecificDNA Methyltransferase 1, HemK Methyltransferase Family Member 2, M.HsaHemK2P, C21orf127,HEMK2, Chromosome 21 Open Reading Frame 127, N6-DNA-Methyltransferase, EC2.1.1.- , PRED28, N6AMT, MTQ2, HemK methyltransferase family member 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:N6AMT1 protein solution (0.25 mg/ml) containing Phosphatebuffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGENFA TPFHGHVGRG AFSDVYEPAE DTFLLLNALE AAAAELAGVEICLEVGSGSG VVSAFLASMI GPQALYMCTD INPEAAACTL ETARCNKVHI QPVITDLVKG LLPRLTEKVDLLVFNPPYVV TPPQEVGSHG IEAAWAGGRN GREVMDRFFPLVPDLLSPRG LFYLVTIKEN NPEEILKIMK TKGLQGTTAL SRQAGQETLSVLKFTKS

N-6 Adenine-Specific DNA Methyltransferase 1, also known as N6AMT1 ispart of the methyltransferase family. N6AMT1 is implicated in the methylationof release factor I  during translationtermination. In addition, N6AMT1 is involved in converting the arsenicmetabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. 

N6AMT1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 237 amino acids (1-214 a.a) andhaving a molecular mass of 25.3kDa.N6AMT1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:N6AMT1: Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. Belongs to the eukaryotic/archaeal PrmC-related family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.1.1.-; Methyltransferase

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: protein complex

Molecular Function:protein binding; nucleic acid binding; protein methyltransferase activity

Biological Process: protein amino acid methylation; positive regulation of cell growth

NCBI Summary:This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]
UniProt Code:Q9Y5N5
NCBI GenInfo Identifier:313104228
NCBI Gene ID:29104
NCBI Accession:Q9Y5N5.3
UniProt Secondary Accession:Q9Y5N5,Q96F73,
UniProt Related Accession:Q9Y5N5
Molecular Weight:Calculated MW: 19kDa/22kDaObserved MW: 23kDa
NCBI Full Name:HemK methyltransferase family member 2
NCBI Synonym Full Names:N-6 adenine-specific DNA methyltransferase 1 (putative)
NCBI Official Symbol:N6AMT1  
NCBI Official Synonym Symbols:MTQ2; HEMK2; N6AMT; PRED28; C21orf127; m.HsaHemK2P  
NCBI Protein Information:hemK methyltransferase family member 2; N6-DNA-methyltransferase; n(6)-adenine-specific DNA methyltransferase 1
UniProt Protein Name:HemK methyltransferase family member 2
UniProt Synonym Protein Names:M.HsaHemK2P; N(6)-adenine-specific DNA methyltransferase 1
Protein Family:HemK methyltransferase family
UniProt Gene Name:N6AMT1  
UniProt Entry Name:HEMK2_HUMAN
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