Human Myoglobin Recombinant Protein (RPPB4043)
- SKU:
- RPPB4043
- Product type:
- Recombinant Protein
- Size:
- 50ug
- Species:
- Human
- Target:
- Myoglobin
- Synonyms:
- Myoglobin
- MB
- PVALB
- MGC13548
- Source:
- Escherichia Coli
- Uniprot:
- P02144
Description
| Product Name: | Human Myoglobin Recombinant Protein |
| Product Code: | RPPB4043 |
| Size: | 50µg |
| Species: | Human |
| Target: | Myoglobin |
| Synonyms: | Myoglobin, MB, PVALB, MGC13548. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered brownish solution. |
| Formulation: | The sterile solution contains phosphate-buffered saline (pH 7.4) and 0.05% NaN3. |
| Stability: | Myoglobin should be stored at 4°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please do not freeze. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
Myoglobin is a member of the globin superfamily and can be found in skeletal and cardiac muscles. It is a haemoprotein that contributs to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. Myoglobin has a single-chain globular structure of 153 amino acids, containing a heme prosthetic group (iron-containing porphyrin) in the core around which the remaining apoprotein folds. Myoglobin has 8 alpha helices and a hydrophobic core. Myoglobin’s molecular weight is 16.7 kDa, and it is the primary oxygen-carrying pigment of muscle tissues. The binding of oxygen in myoglobin is different from the cooperative oxygen binding in hemoglobin, since positive collaboration is a property of multimeric/oligomeric proteins only. Instead, the binding of oxygen by myoglobin is uninfluenced by the oxygen pressure in the surrounding tissue. Myoglobin is frequently referred to as having an "instant binding tenacity" to oxygen given its hyperbolic oxygen dissociation curve. Different organisms are able to hold their breaths longer due to high concentrations of myoglobin in their muscle cells. Myoglobin is responsible for the pigments that make meat red. The color of the meat is partly determined by the charge of the iron atom in myoglobin and the oxygen attached to it. Myoglobin is found in Type I muscle, Type II A and Type II B, but it is mostly deemed that myoglobin is not found in smooth muscle. Myoglobin is discharged from damaged muscle tissue (rhabdomyolysis), which contains very high concentrations of myoglobin. Even though the released myoglobin is filtered by the kidneys, it is toxic to the renal tubular epithelium and thus may cause acute renal failure.
Myoglobin Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 17.67 kDa. The Myoglobin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MB: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 22q13.1 Molecular Function:iron ion binding; heme binding; oxygen binding; oxygen transporter activity Biological Process: slow-twitch skeletal muscle fiber contraction; response to hydrogen peroxide; oxygen transport; heart development; response to hormone stimulus; brown fat cell differentiation; response to hypoxia; enucleate erythrocyte differentiation |
| NCBI Summary: | This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02144 |
| NCBI GenInfo Identifier: | 127661 |
| NCBI Gene ID: | 4151 |
| NCBI Accession: | P02144.2 |
| UniProt Secondary Accession: | P02144,Q52H51, Q5THY7, |
| UniProt Related Accession: | P02144 |
| Molecular Weight: | 17,184 Da |
| NCBI Full Name: | Myoglobin |
| NCBI Synonym Full Names: | myoglobin |
| NCBI Official Symbol: | MB |
| NCBI Official Synonym Symbols: | PVALB; myoglobgin |
| NCBI Protein Information: | myoglobin |
| UniProt Protein Name: | Myoglobin |
| Protein Family: | Myoglobin |
| UniProt Gene Name: | MB |
| UniProt Entry Name: | MYG_HUMAN |
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