Human MYLPF Recombinant Protein (RPPB4042)

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SKU:
RPPB4042
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MYLPF
Synonyms:
Myosin regulatory light chain 2 skeletal muscle isoform
Synonyms:
Fast skeletal myosin light chain 2
Synonyms:
MLC2B
Synonyms:
MYLPF
Source:
Escherichia Coli
Uniprot:
Q96A32
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Description

Product Name:Human MYLPF Recombinant Protein
Product Code:RPPB4042
Size:10µg
Species:Human
Target:MYLPF
Synonyms:Myosin regulatory light chain 2 skeletal muscle isoform, Fast skeletal myosin light chain 2, MLC2B, MYLPF, MRLC2, MYL11, HUMMLC2B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MYLPF protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAPKRAKRRT VEGGSSSVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL RDTFAAMGRL NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI TGAFKVLDPE GKGTIKKKFL EELLTTQCDR FSQEEIKNMW AAFPPDVGGN VDYKNICYVI THGDAKDQE

Myosin regulatory light chains, including MRCL3, MYLPF and MYL9, regulate contraction in smooth muscle and non-muscle cells via phosphorylation by MLCK (myosin light chain kinase). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the actin-activated myosin ATPase activity, thus regulating the contractile activity. MYLPF is vital for fast and slow skeletal muscle development.

MYLPF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (1-169 a.a) and having a molecular mass of 21.2kDa.MYLPF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MYLPF: Myosin is an hexamer of 2 heavy chains and 4 light chains.Protein type: Motility/polarity/chemotaxis; MotorChromosomal Location of Human Ortholog: 16p11.2Cellular Component: cytosol; lysosomal membrane; muscle myosin complexMolecular Function: structural constituent of muscleBiological Process: muscle contraction; skeletal muscle development
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96A32
NCBI GenInfo Identifier:1025812261
NCBI Gene ID:29895
NCBI Accession:NP_001311387.1
UniProt Secondary Accession:Q96A32,Q14843, Q6IB41, B2RA83
UniProt Related Accession:Q96A32
Molecular Weight:34.87kD
NCBI Full Name:myosin regulatory light chain 2, skeletal muscle isoform
NCBI Synonym Full Names:myosin light chain, phosphorylatable, fast skeletal muscle
NCBI Official Symbol:MYLPF  
NCBI Official Synonym Symbols:MLC2B; MRLC2; MYL11; HUMMLC2B  
NCBI Protein Information:myosin regulatory light chain 2, skeletal muscle isoform
UniProt Protein Name:Myosin regulatory light chain 2, skeletal muscle isoform
UniProt Synonym Protein Names:Fast skeletal myosin light chain 2; MLC2B
Protein Family:Myosin regulatory
UniProt Gene Name:MYLPF  
UniProt Entry Name:
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