Human MYL1 Recombinant Protein (RPPB4030)

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SKU:
RPPB4030
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MYL1
Synonyms:
Myosin light chain 1 skeletal muscle isoform
Synonyms:
MLC1F
Synonyms:
A1 catalytic
Synonyms:
Alkali myosin light chain 1
Source:
Escherichia Coli
Uniprot:
P05976
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Description

Product Name:Human MYL1 Recombinant Protein
Product Code:RPPB4030
Size:10µg
Species:Human
Target:MYL1
Synonyms:Myosin light chain 1 skeletal muscle isoform, MLC1F, A1 catalytic, Alkali myosin light chain 1, MYL1, MLC3F.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Human MYL1 in 10mM Tris -HCI, 1mM EDTA PH 7.5.
Stability:Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.

Myosin is a hexameric ATPase cellular motor protein, which is composed of 2 heavy chains, 2 non-phosphorylatable alkali light chains, and 2 phosphorylatable regulatory light chains. MYL1 gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for the MYL1 gene. In humans MYL1 is localized to chromosome 2q32.1-qter. The Myl1 locus encodes two alkali myosin light chains- Mlc1f and Mlc3f, from two promoters that are differentially regulated throughout development. The Mlc1f promoter is active in embryonic, fetal and adult fast skeletal muscle while the Mlc3f promoter is upregulated during fetal development and stays on in adult fast skeletal muscle.

Recombinant Human Ventricular Myosin Light Chain-1 (MYL1) protein has a molecular mass of 25 kDa and is fused to 7 amino acids at N-terminus. The MYL1 protein was affinity purified using anti MYL1 monoclonal antibody 39-15 column.

UniProt Protein Function:MYL1: Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Contractile

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: sarcomere; myofibril; muscle myosin complex; cytosol

Molecular Function:structural constituent of muscle; calcium ion binding

Biological Process: muscle contraction; muscle filament sliding; cardiac muscle contraction

NCBI Summary:Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P05976
NCBI GenInfo Identifier:17986273
NCBI Gene ID:4632
NCBI Accession:NP_524144.1
UniProt Secondary Accession:P05976,P06741, Q6IBD5, B2R4N6, B2R4T6,
UniProt Related Accession:P05976
Molecular Weight:16,684 Da
NCBI Full Name:myosin light chain 1/3, skeletal muscle isoform isoform 1f
NCBI Synonym Full Names:myosin, light chain 1, alkali; skeletal, fast
NCBI Official Symbol:MYL1  
NCBI Official Synonym Symbols:MLC1F; MLC3F  
NCBI Protein Information:myosin light chain 1/3, skeletal muscle isoform; A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F/MLC3F; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light polypeptide 1, alkali; skeletal, fast
UniProt Protein Name:Myosin light chain 1/3, skeletal muscle isoform
UniProt Synonym Protein Names:Myosin light chain alkali 1/2; Myosin light chain A1/A2
Protein Family:Myosin
UniProt Gene Name:MYL1  
UniProt Entry Name:MYL1_HUMAN
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