Human MYL1 Recombinant Protein (RPPB4030)
- SKU:
- RPPB4030
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- MYL1
- Synonyms:
- Myosin light chain 1 skeletal muscle isoform
- MLC1F
- A1 catalytic
- Alkali myosin light chain 1
- Source:
- Escherichia Coli
- Uniprot:
- P05976
Description
| Product Name: | Human MYL1 Recombinant Protein |
| Product Code: | RPPB4030 |
| Size: | 10µg |
| Species: | Human |
| Target: | MYL1 |
| Synonyms: | Myosin light chain 1 skeletal muscle isoform, MLC1F, A1 catalytic, Alkali myosin light chain 1, MYL1, MLC3F. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | Human MYL1 in 10mM Tris -HCI, 1mM EDTA PH 7.5. |
| Stability: | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
Myosin is a hexameric ATPase cellular motor protein, which is composed of 2 heavy chains, 2 non-phosphorylatable alkali light chains, and 2 phosphorylatable regulatory light chains. MYL1 gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for the MYL1 gene. In humans MYL1 is localized to chromosome 2q32.1-qter. The Myl1 locus encodes two alkali myosin light chains- Mlc1f and Mlc3f, from two promoters that are differentially regulated throughout development. The Mlc1f promoter is active in embryonic, fetal and adult fast skeletal muscle while the Mlc3f promoter is upregulated during fetal development and stays on in adult fast skeletal muscle.
Recombinant Human Ventricular Myosin Light Chain-1 (MYL1) protein has a molecular mass of 25 kDa and is fused to 7 amino acids at N-terminus. The MYL1 protein was affinity purified using anti MYL1 monoclonal antibody 39-15 column.
| UniProt Protein Function: | MYL1: Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Contractile Chromosomal Location of Human Ortholog: 2q33-q34 Cellular Component: sarcomere; myofibril; muscle myosin complex; cytosol Molecular Function:structural constituent of muscle; calcium ion binding Biological Process: muscle contraction; muscle filament sliding; cardiac muscle contraction |
| NCBI Summary: | Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05976 |
| NCBI GenInfo Identifier: | 17986273 |
| NCBI Gene ID: | 4632 |
| NCBI Accession: | NP_524144.1 |
| UniProt Secondary Accession: | P05976,P06741, Q6IBD5, B2R4N6, B2R4T6, |
| UniProt Related Accession: | P05976 |
| Molecular Weight: | 16,684 Da |
| NCBI Full Name: | myosin light chain 1/3, skeletal muscle isoform isoform 1f |
| NCBI Synonym Full Names: | myosin, light chain 1, alkali; skeletal, fast |
| NCBI Official Symbol: | MYL1 |
| NCBI Official Synonym Symbols: | MLC1F; MLC3F |
| NCBI Protein Information: | myosin light chain 1/3, skeletal muscle isoform; A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F/MLC3F; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light polypeptide 1, alkali; skeletal, fast |
| UniProt Protein Name: | Myosin light chain 1/3, skeletal muscle isoform |
| UniProt Synonym Protein Names: | Myosin light chain alkali 1/2; Myosin light chain A1/A2 |
| Protein Family: | Myosin |
| UniProt Gene Name: | MYL1 |
| UniProt Entry Name: | MYL1_HUMAN |
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