Human MVD Recombinant Protein (RPPB1988)
- SKU:
- RPPB1988
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- MVD
- Synonyms:
- Diphosphomevalonate decarboxylase
- Mevalonate (diphospho)decarboxylase
- MDDase
- Mevalonate pyrophosphate decarboxylase
- Source:
- Escherichia Coli
- Uniprot:
- P53602
Description
| Product Name: | Human MVD Recombinant Protein |
| Product Code: | RPPB1988 |
| Size: | 10µg |
| Species: | Human |
| Target: | MVD |
| Synonyms: | Diphosphomevalonate decarboxylase, Mevalonate (diphospho)decarboxylase, MDDase, Mevalonate pyrophosphate decarboxylase, MVD, MPD, FP17780. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MVD solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASEKPLAAV TCTAPVNIAV IKYWGKRDEE LVLPINSSLS VTLHQDQLKT TTTAVISKDF TEDRIWLNGR EEDVGQPRLQ ACLREIRCLA RKRRNSRDGD PLPSSLSCKV HVASVNNFPT AAGLASSAAG YACLAYTLAR VYGVESDLSE VARRGSGSAC RSLYGGFVEW QMGEQADGKD SIARQVAPES HWPELRVLIL VVSAEKKLTG STVGMRASVE TSPLLRFRAE SVVPARMAEM ARCIRERDFP SFAQLTMKDS NQFHATCLDT FPPISYLNAI SWRIIHLVHR FNAHHGDTKV AYTFDAGPNA VIFTLDDTVA EFVAAVWHGF PPGSNGDTFL KGLQVRPAPL SAELQAALAM EPTPGGVKYI IVTQVGPGPQ ILDDPCAHLL GPDGLPKPAA |
Diphosphomevalonate decarboxylase (MVD) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. MVD decarboxylates and dehydrates its substrate while hydrolyzing ATP. MVD is expressed in the heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.
MVD Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 420 amino acids (1-400) and having a molecular mass of 45.6kDa.MVD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MVD: Performs the first committed step in the biosynthesis of isoprenes. Belongs to the diphosphomevalonate decarboxylase family. |
| UniProt Protein Details: | Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lyase; EC 4.1.1.33 Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: cytosol; peroxisome Molecular Function:diphosphomevalonate decarboxylase activity; Hsp70 protein binding; protein homodimerization activity Biological Process: cholesterol biosynthetic process; dolichyl diphosphate biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; positive regulation of cell proliferation |
| NCBI Summary: | The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53602 |
| NCBI GenInfo Identifier: | 1706681 |
| NCBI Gene ID: | 4597 |
| NCBI Accession: | P53602.1 |
| UniProt Secondary Accession: | P53602,Q53Y65, |
| UniProt Related Accession: | P53602 |
| Molecular Weight: | 43,405 Da |
| NCBI Full Name: | Diphosphomevalonate decarboxylase |
| NCBI Synonym Full Names: | mevalonate diphosphate decarboxylase |
| NCBI Official Symbol: | MVD |
| NCBI Official Synonym Symbols: | MPD; MDDase; POROK7; FP17780 |
| NCBI Protein Information: | diphosphomevalonate decarboxylase |
| UniProt Protein Name: | Diphosphomevalonate decarboxylase |
| UniProt Synonym Protein Names: | Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase |
| UniProt Gene Name: | MVD |
| UniProt Entry Name: | MVD1_HUMAN |
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