Human MSRB3 Recombinant Protein (RPPB1982)
- SKU:
- RPPB1982
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- MSRB3
- Synonyms:
- Methionine-R-sulfoxide reductase B3
- MSRB3
- DFNB74
- FLJ36866
- Source:
- Escherichia Coli
- Uniprot:
- Q8IXL7
Description
| Product Name: | Human MSRB3 Recombinant Protein |
| Product Code: | RPPB1982 |
| Size: | 10µg |
| Species: | Human |
| Target: | MSRB3 |
| Synonyms: | Methionine-R-sulfoxide reductase B3, MSRB3, DFNB74, FLJ36866, DKFZp686C1178. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MSRB3 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MCGLPSGSCR DKKNCKVVFS QQELRKRLTP LQYHVTQEKG TESAFEGEYT HHKDPGIYKC VVCGTPLFKS ETKFDSGSGW PSFHDVINSE AITFTDDFSY GMHRVETSCS QCGAHLGHIF DDGPRPTGKR YCINSAALSF TPADSSGTAE GGSGVASPAQ ADKAELLEHH HHHH |
Methionine sulfoxide reductase B3 (MSRB3) is a member of the methionine sulfoxide reductases (MSR) family proteins. MSRB3 catalyzes the reduction of methionine sulfoxide to methionine. The MSRB3 enzyme acts as a monomer and requires zinc as a cofactor. MSRs are thought to defend against reactive oxygen species-induced oxidative damage in various organs, including the most environmentally exposed organ, the human skin. MSRB3 has a vital role in cold tolerance by eliminating MetO and ROS which accumulate at the ER during cold acclimation.
MSRB3 Human Recombinant fused with an 8 amino acid His tag at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 174 amino acids (21-185 a.a.) and having a molecular mass of 19kDa. The MSRB3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. |
| NCBI Summary: | The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q8IXL7 |
| NCBI GenInfo Identifier: | 73089054 |
| NCBI Gene ID: | 253827 |
| NCBI Accession: | NP_001026849.1 |
| UniProt Secondary Accession: | Q8IXL7,Q6UXS2, B4DR19, B7ZAQ0, |
| UniProt Related Accession: | Q8IXL7 |
| Molecular Weight: | 20,010 Da |
| NCBI Full Name: | methionine-R-sulfoxide reductase B3 isoform 2 |
| NCBI Synonym Full Names: | methionine sulfoxide reductase B3 |
| NCBI Official Symbol: | MSRB3 |
| NCBI Official Synonym Symbols: | DFNB74 |
| NCBI Protein Information: | methionine-R-sulfoxide reductase B3 |
| UniProt Protein Name: | Methionine-R-sulfoxide reductase B3 |
| Protein Family: | Methionine-R-sulfoxide reductase |
| UniProt Gene Name: | MSRB3 |
| UniProt Entry Name: | MSRB3_HUMAN |
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