Human MSRA Recombinant Protein (RPPB1979)
- SKU:
- RPPB1979
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- MSRA
- Synonyms:
- Mitochondrial peptide methionine sulfoxide reductase
- Peptide-methionine (S)-S-oxide reductase
- Peptide Met(O) reductase
- Protein-methionine-S-oxide reductase
- Source:
- Escherichia Coli
- Uniprot:
- Q9UJ68
Description
| Product Name: | Human MSRA Recombinant Protein |
| Product Code: | RPPB1979 |
| Size: | 20µg |
| Species: | Human |
| Target: | MSRA |
| Synonyms: | Mitochondrial peptide methionine sulfoxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase, PMSR, MSRA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | MSRA protein solution (0.5mg/ml) is supplied in 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 1mM DTT and 50mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMGNSAS NIVSPQEALP GRKEQTPVAA KHHVNGNRTV EPFPEGTQMA VFGMGCFWGA ERKFWVLKGV YSTQVGFAGG YTSNPTYKEV CSEKTGHAEV VRVVYQPEHM SFEELLKVFW ENHDPTQGMR QGNDHGTQYR SAIYPTSAKQ MEAALSSKEN YQKVLSEHGF GPITTDIREG QTFYYAEDYH QQYLSKNPNG YCGLGGTGVS CPVGIKK |
Methionine sulfoxide reductase A (MSRA) is a member of the MsrA Met sulfoxide reductase family. The MSRA enzyme has a vital function as a repair enzyme for proteins which have been inactivated by oxidation. MSRA catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. The three substrates of the MSRA enzyme are peptide-L-methionine, thioredoxin disulfide, and H2O, while its 2 products are peptide-L-methionine (R)-S-oxide and thioredoxin. The MSRA protein is ubiquitous and extremely conserved. Human and animal studies have shown the ultimate levels of expression in kidney and nervous tissue.
MSRA Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (24-235) and having a molecular mass of 26.2kDa.The MSRA is fused to a 24 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MSRA: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. 5 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.8.4.11 Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: actin cytoskeleton; cytoplasm; cytosol; nucleoplasm Molecular Function:peptide-methionine-(S)-S-oxide reductase activity Biological Process: methionine metabolic process; protein modification process; protein repair |
| NCBI Summary: | This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9UJ68 |
| NCBI GenInfo Identifier: | 12230350 |
| NCBI Gene ID: | 4482 |
| NCBI Accession: | Q9UJ68.1 |
| UniProt Secondary Accession: | Q9UJ68,Q52TC4, Q549N4, Q66MI7, E9PAS8, |
| UniProt Related Accession: | Q9UJ68 |
| Molecular Weight: | 23,627 Da |
| NCBI Full Name: | Mitochondrial peptide methionine sulfoxide reductase |
| NCBI Synonym Full Names: | methionine sulfoxide reductase A |
| NCBI Official Symbol: | MSRA |
| NCBI Official Synonym Symbols: | PMSR |
| NCBI Protein Information: | mitochondrial peptide methionine sulfoxide reductase |
| UniProt Protein Name: | Mitochondrial peptide methionine sulfoxide reductase |
| UniProt Synonym Protein Names: | Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR |
| Protein Family: | Mitochondrial peptide methionine sulfoxide reductase |
| UniProt Gene Name: | MSRA |
| UniProt Entry Name: | MSRA_HUMAN |
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