Human MSR1 Recombinant Protein (RPPB4013)

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SKU:
RPPB4013
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MSR1
Synonyms:
Macrophage Scavenger Receptor 1
Synonyms:
Macrophage AcetylatedLDL Receptor I And II
Synonyms:
Scavenger Receptor Class A Member 1
Synonyms:
SCARA1
Source:
Sf9 Insect cells
Uniprot:
P21757
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Description

Product Name:Human MSR1 Recombinant Protein
Product Code:RPPB4013
Size:10µg
Species:Human
Target:MSR1
Synonyms:Macrophage Scavenger Receptor 1, Macrophage AcetylatedLDL Receptor I And II, Scavenger Receptor Class A Member 1, SCARA1, MacrophageScavenger Receptor Type III, CD204Antigen, CD204, PhSR1, PhSR2, SR-A, SRA.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MSR1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPKWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTLHH HHHH

Macrophage Scavenger Receptor 1, also known as MSR1 is a member of the class A macrophage scavenger receptors, which comprises three different types 1, 2 and 3 generated by alternative splicing. Furthermore, these receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological as well as pathological processes which include atherosclerosis, Alzheimer's disease, and host defense.

MSR1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 384 amino acids (77-451 a.a.) andhaving a molecular mass of 42.4kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions). MSR1 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:low-density lipoprotein binding; protein binding

Biological Process: cholesterol transport; receptor-mediated endocytosis

Disease: Barrett Esophagus; Prostate Cancer

NCBI Summary:This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
UniProt Code:P21757
NCBI GenInfo Identifier:127357
NCBI Gene ID:4481
NCBI Accession:P21757.1
UniProt Secondary Accession:P21757,O60505, P21759, Q45F10, D3DSP3,
UniProt Related Accession:P21757
Molecular Weight:42,942 Da
NCBI Full Name:Macrophage scavenger receptor types I and II
NCBI Synonym Full Names:macrophage scavenger receptor 1
NCBI Official Symbol:MSR1  
NCBI Official Synonym Symbols:SRA; SR-A; CD204; phSR1; phSR2; SCARA1  
NCBI Protein Information:macrophage scavenger receptor types I and II
UniProt Protein Name:Macrophage scavenger receptor types I and II
UniProt Synonym Protein Names:Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD_antigen: CD204
Protein Family:Macrophage scavenger receptor
UniProt Gene Name:MSR1  
UniProt Entry Name:MSRE_HUMAN
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