Human MSMB Recombinant Protein (RPPB4329)

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SKU:
RPPB4329
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MSMB
Synonyms:
Beta-microseminoprotein
Synonyms:
Prostate secreted seminal plasma protein
Synonyms:
Prostate secretory protein PSP94
Synonyms:
Seminal plasma beta-inhibin
Source:
Escherichia Coli
Uniprot:
P08118
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Description

Product Name:Human MSMB Recombinant Protein
Product Code:RPPB4329
Size:10µg
Species:Human
Target:MSMB
Synonyms:Beta-microseminoprotein, Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, Seminal plasma beta-inhibin, Immunoglobulin-binding factor, MSP, PSP, PSP57, PSP94, PSP-94, MSP-beta, beta-MSP, Microseminoprotein, IGBF, PN44, MSMB, MSP-B, MSPB, PRPS, Prostatic Secretory Protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The sterile filtered concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5.
Solubility:Add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS SCYFIPNEGV PGDSTRKCMD LKGNKHPINS EWQTDNCETC TCYETEISCC TLVSTPVGYD KDNCQRIFKK EDCKYIVVEK KDPKKTCSVSEWII

Microseminoprotein is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.

MSMB Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 104 amino acids and having a molecular mass of 12 kDa. The MSMB is fused to His tag at N-Terminus.The Human MSMB is purified by proprietary chromatographic techniques.

UniProt Protein Function:MSMB: Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the beta-microseminoprotein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nucleus

Disease: Prostate Cancer, Hereditary, 13

NCBI Summary:The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08118
NCBI GenInfo Identifier:131436
NCBI Gene ID:4477
NCBI Accession:P08118.1
UniProt Secondary Accession:P08118,P11999, Q13125, Q6IAY9, Q9UC59, B1API6,
UniProt Related Accession:P08118
Molecular Weight:114
NCBI Full Name:Beta-microseminoprotein
NCBI Synonym Full Names:microseminoprotein, beta-
NCBI Official Symbol:MSMB  
NCBI Official Synonym Symbols:MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94  
NCBI Protein Information:beta-microseminoprotein; seminal plasma beta-inhibin; immunoglobulin binding factor; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids
UniProt Protein Name:Beta-microseminoprotein
UniProt Synonym Protein Names:Immunoglobulin-binding factor; IGBF; PN44; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids; PSP-94; PSP94; Seminal plasma beta-inhibin
Protein Family:Methanesulfonate monooxygenase hydroxylase
UniProt Gene Name:MSMB  
UniProt Entry Name:MSMB_HUMAN
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