PE/Cyanine7 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0674)

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SKU:
AGEL0674
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The CD47 Monoclonal Antibody (PE/Cyanine7 Conjugated) is a powerful tool for researchers studying CD47, a transmembrane protein known for its role in immune evasion and cancer cell survival. This monoclonal antibody, designated MIAP410 (AGEL0674), is specifically conjugated with PE/Cyanine7 for versatile flow cytometry applications across human, mouse, and rat samples. By targeting CD47, this antibody enables the precise detection and analysis of this key protein in a variety of cell types, making it ideal for investigating immune responses and cancer biology.CD47, also recognized as a "don't eat me" signal, is a crucial player in evading phagocytosis by macrophages and other immune cells.

Its overexpression is commonly associated with various cancer types, allowing tumor cells to escape immune surveillance and promote tumor growth. The antibody's ability to bind to CD47 facilitates the exploration of its function in the context of cancer progression, immunotherapy resistance, and autoimmune diseases. By unraveling the mechanisms underlying CD47's interactions, researchers can develop targeted strategies to manipulate immune responses for therapeutic benefits.

Product Title:PE/Cyanine7 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0674
Size:20 Tests, 100 Tests, 200 Tests
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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