APC Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0671)

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SKU:
AGEL0671
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Mouse
Rat
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
MIAP410
Conjugation:
APC
Frequently bought together:

Description

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APC Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The APC-conjugated Monoclonal Antibody MIAP410 (AGEL0671) offered by Assay Genie is a specialized research tool designed for the detection of CD47, a transmembrane protein involved in diverse cellular processes, particularly in immune response and cancer progression. This antibody, specifically targeting human, mouse, and rat CD47, is optimized for flow cytometry applications, allowing for accurate quantification and analysis of CD47 expression in various cell types.CD47, also known as integrin-associated protein, plays a pivotal role in immune regulation and self-recognition processes. It is implicated in the modulation of phagocytosis, apoptosis, and immune evasion mechanisms, making it a key player in cancer immune evasion strategies.

Understanding the dynamics of CD47 expression and function is crucial in elucidating its role in cancer biology and immunotherapy development.By utilizing the APC-conjugated Monoclonal Antibody MIAP410 (AGEL0671), researchers can delve deeper into the intricate mechanisms involving CD47, unveiling potential therapeutic targets for cancer treatment and immunomodulation strategies. The high specificity and reliability of this antibody make it an indispensable tool for investigations in oncology, immunology, and related fields, paving the way for innovative advancements in precision medicine and targeted therapies.

Product Title:APC Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0671
Size:20 Tests, 100 Tests, 200 Tests
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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