Human MOB1B Recombinant Protein (RPPB2584)
- SKU:
- RPPB2584
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- MOB1B
- Synonyms:
- MOBKinase Activator 1B
- Mps One Binder Kinase Activator-Like 1A
- Mob1 Homolog 1A
- MOBKL1A
- Source:
- Escherichia Coli
- Uniprot:
- Q7L9L4
Frequently bought together:
Description
| Product Name: | Human MOB1B Recombinant Protein |
| Product Code: | RPPB2584 |
| Size: | 20µg |
| Species: | Human |
| Target: | MOB1B |
| Synonyms: | MOBKinase Activator 1B, Mps One Binder Kinase Activator-Like 1A, Mob1 Homolog 1A, MOBKL1A,Mob1A, MOB4A, MOB1, Mps One Binder Kinase Activator-Like 1A (Yeast), MOB1, MpsOne Binder Kinase Activator-Like 1A, MOB1 Mps One Binder Homolog B (Yeast), MOB1Mps One Binder Homolog B, Mob4A Protein, MATS2, Mob1B, MOB kinase activator 1B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MOB1Bprotein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl,30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSMSFLFGSRSSKTFKPKK NIPEGSHQYE LLKHAEATLG SGNLRMAVML PEGEDLNEWV AVNTVDFFNQ INMLYGTITDFCTEESCPVM SAGPKYEYHW ADGTNIKKPI KCSAPKYIDY LMTWVQDQLD DETLFPSKIG VPFPKNFMSVAKTILKRLFR VYAHIYHQHF DPVIQLQEEA HLNTSFKHFI FFVQEFNLID RRELAPLQEL IEKLTSKDR |
MOB Kinase Activator 1B (MOB1B) is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, which is a protein kinase vital for spindle pole body duplication and mitotic checkpoint regulation.
MOB1B Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 239 amino acids (1-216 a.a) andhaving a molecular mass of 27kDa.MOB1B is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.
| UniProt Protein Function: | MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:kinase activator activity; kinase binding; protein binding Biological Process: regulation of protein amino acid autophosphorylation |
| NCBI Summary: | The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q7L9L4 |
| NCBI GenInfo Identifier: | 56749324 |
| NCBI Gene ID: | 92597 |
| NCBI Accession: | Q7L9L4.3 |
| UniProt Secondary Accession: | Q7L9L4,Q8IY23, B2R8U6, B4DRY3, |
| UniProt Related Accession: | Q7L9L4 |
| Molecular Weight: | 25,499 Da |
| NCBI Full Name: | MOB kinase activator 1B |
| NCBI Synonym Full Names: | MOB kinase activator 1B |
| NCBI Official Symbol: | MOB1B |
| NCBI Official Synonym Symbols: | MATS2; MOB4A; MOBKL1A |
| NCBI Protein Information: | MOB kinase activator 1B |
| UniProt Protein Name: | MOB kinase activator 1B |
| UniProt Synonym Protein Names: | Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1B |
| UniProt Entry Name: | MOB1B_HUMAN |
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