Human MOB1B Recombinant Protein (RPPB2584)

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SKU:
RPPB2584
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MOB1B
Synonyms:
MOBKinase Activator 1B
Synonyms:
Mps One Binder Kinase Activator-Like 1A
Synonyms:
Mob1 Homolog 1A
Synonyms:
MOBKL1A
Source:
Escherichia Coli
Uniprot:
Q7L9L4
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Description

Product Name:Human MOB1B Recombinant Protein
Product Code:RPPB2584
Size:20µg
Species:Human
Target:MOB1B
Synonyms:MOBKinase Activator 1B, Mps One Binder Kinase Activator-Like 1A, Mob1 Homolog 1A, MOBKL1A,Mob1A, MOB4A, MOB1, Mps One Binder Kinase Activator-Like 1A (Yeast), MOB1, MpsOne Binder Kinase Activator-Like 1A, MOB1 Mps One Binder Homolog B (Yeast), MOB1Mps One Binder Homolog B, Mob4A Protein, MATS2, Mob1B, MOB kinase activator 1B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MOB1Bprotein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl,30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMSFLFGSRSSKTFKPKK NIPEGSHQYE LLKHAEATLG SGNLRMAVML PEGEDLNEWV AVNTVDFFNQ INMLYGTITDFCTEESCPVM SAGPKYEYHW ADGTNIKKPI KCSAPKYIDY LMTWVQDQLD DETLFPSKIG VPFPKNFMSVAKTILKRLFR VYAHIYHQHF DPVIQLQEEA HLNTSFKHFI FFVQEFNLID RRELAPLQEL IEKLTSKDR

MOB Kinase Activator 1B (MOB1B) is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, which is a protein kinase vital for spindle pole body duplication and mitotic checkpoint regulation.

MOB1B Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 239 amino acids (1-216 a.a) andhaving a molecular mass of 27kDa.MOB1B is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.

UniProt Protein Function:MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Activator

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:kinase activator activity; kinase binding; protein binding

Biological Process: regulation of protein amino acid autophosphorylation

NCBI Summary:The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q7L9L4
NCBI GenInfo Identifier:56749324
NCBI Gene ID:92597
NCBI Accession:Q7L9L4.3
UniProt Secondary Accession:Q7L9L4,Q8IY23, B2R8U6, B4DRY3,
UniProt Related Accession:Q7L9L4
Molecular Weight:25,499 Da
NCBI Full Name:MOB kinase activator 1B
NCBI Synonym Full Names:MOB kinase activator 1B
NCBI Official Symbol:MOB1B  
NCBI Official Synonym Symbols:MATS2; MOB4A; MOBKL1A  
NCBI Protein Information:MOB kinase activator 1B
UniProt Protein Name:MOB kinase activator 1B
UniProt Synonym Protein Names:Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A
Protein Family:MOB kinase activator
UniProt Gene Name:MOB1B  
UniProt Entry Name:MOB1B_HUMAN
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