Human MIA2 Recombinant Protein (RPPB0769)
- SKU:
- RPPB0769
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- MIA2
- Synonyms:
- MIA-2
- MIA2
- Melanoma Inhibitory Activity 2
- FLJ22404
- Source:
- Escherichia Coli
- Uniprot:
- Q96PC5
Frequently bought together:
Description
| Product Name: | Human MIA2 Recombinant Protein |
| Product Code: | RPPB0769 |
| Size: | 20µg |
| Species: | Human |
| Target: | MIA2 |
| Synonyms: | MIA-2, MIA2, Melanoma Inhibitory Activity 2, FLJ22404. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The MIA2 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Phosphate buffer pH=7.4 and 150mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized MIA2 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized MIA2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIA2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MLESTKLLAD LKKCGDLECE ALINRVSAMR DYRGPDCRYL NFTKGEEISV YVKLAGERED LWAGSKGKEF GYFPRDAVQI EEVFISEEIQ MSTKESDFLC L |
MIA2 performs as a tumour suppressor in hepatocellular carcinoma. MIA2is a novel acute phase protein which its expression is found in the liver and reacts to liver damage in chronic liver diseases and is considerably higher in severe fibrosis patients . MIA2 is induced by IL6, TGF-B & and conditioned medium from activated hepatic stellate cells. MIA2 is is mainly expressed in hepatocytes.
MIA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 101 amino having a total molecular mass of 11.5 kDa.The MIA2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MIA2: May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage. Belongs to the MIA/OTOR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 14q13.2Cellular Component: extracellular regionBiological Process: cholesterol homeostasis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PC5 |
| NCBI GenInfo Identifier: | 308153584 |
| NCBI Gene ID: | 117153 |
| NCBI Accession: | Q96PC5.3 |
| UniProt Secondary Accession: | Q96PC5,Q9H6C1, A1L4H0 |
| UniProt Related Accession: | Q96PC5 |
| Molecular Weight: | 74,089 Da |
| NCBI Full Name: | Melanoma inhibitory activity protein 2 |
| NCBI Synonym Full Names: | melanoma inhibitory activity 2 |
| NCBI Official Symbol: | MIA2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | melanoma inhibitory activity protein 2 |
| UniProt Protein Name: | Melanoma inhibitory activity protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | MIA2 |
| UniProt Entry Name: | MIA2_HUMAN |
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