Human MFAP4 Recombinant Protein (RPPB3968)

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SKU:
RPPB3968
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MFAP4
Synonyms:
Microfibrillar-Associated Protein 4
Synonyms:
Microfibril-Associated Glycoprotein 4
Source:
Escherichia Coli
Uniprot:
P55083
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Description

Product Name:Human MFAP4 Recombinant Protein
Product Code:RPPB3968
Size:20µg
Species:Human
Target:MFAP4
Synonyms:Microfibrillar-Associated Protein 4, Microfibril-Associated Glycoprotein 4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MFAP4 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMVSGIR GDALERFCLQ QPLDCDDIYA QGYQSDGVYL IYPSGPSVPV PVFCDMTTEG GKWTVFQKRF NGSVSFFRGW NDYKLGFGRA DGEYWLGLQN MHLLTLKQKY ELRVDLEDFE NNTAYAKYAD FSISPNAVSA EEDGYTLFVA GFEDGGAGDS LSYHSGQKFS TFDRDQDLFV QNCAALSSGA FWFRSCHFAN LNGFYLGGSH LSYANGINWA QWKGFYYSLK RTEMKIRRA

Microfibrillar-associated protein 4 (MFAP4) is a member of Fibrinogen protein family and contains 1 fibrinogen C-terminal domain. The MFAP4 protein has similarity to a bovine microfibril-associated protein. MFAP4 has binding specificities for both collagen and carbohydrate. MFAP4 is believed to be an extracellular matrix protein that is involved in cell adhesion or intercellular interactions. MFAP4 deletion was found in 30 of 31 Smith-Magenis syndrome (SMS) patients.

MFAP4 Human Recombinant produced in E. coli is a single polypeptide chain containing 259 amino acids (22-255) and having a molecular mass of 29.2 kDa.MFAP4 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MFAP4: Could be involved in calcium-dependent cell adhesion or intercellular interactions. MFAP4 is deleted in the Smith-Magenis syndrome (SMS).
UniProt Protein Details:

Protein type:Secreted; Cell adhesion; Secreted, signal peptide; Calcium-binding

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: extracellular matrix; microfibril; extracellular region

Molecular Function:protein binding

Biological Process: elastic fiber assembly; extracellular matrix organization and biogenesis; UV protection; fibril organization and biogenesis; cell adhesion

NCBI Summary:This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:P55083
NCBI GenInfo Identifier:2506403
NCBI Gene ID:4239
NCBI Accession:P55083.2
UniProt Secondary Accession:P55083,Q6P680, A8KAJ1, A8MVM2, B4E317,
UniProt Related Accession:P55083
Molecular Weight:28,648 Da
NCBI Full Name:Microfibril-associated glycoprotein 4
NCBI Synonym Full Names:microfibrillar-associated protein 4
NCBI Official Symbol:MFAP4  
NCBI Protein Information:microfibril-associated glycoprotein 4
UniProt Protein Name:Microfibril-associated glycoprotein 4
Protein Family:Microfibril-associated glycoprotein
UniProt Gene Name:MFAP4  
UniProt Entry Name:MFAP4_HUMAN
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