Human METTL1 Recombinant Protein (RPPB1939)

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SKU:
RPPB1939
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
METTL1
Synonyms:
Methyltransferase-Like 1
Synonyms:
TRM8
Synonyms:
tRNA(m7G46)-methyltransferase
Synonyms:
tRNA (guanine-N(7)-)-methyltransferase
Source:
Escherichia Coli
Uniprot:
Q9UBP6
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Description

Product Name:Human METTL1 Recombinant Protein
Product Code:RPPB1939
Size:10µg
Species:Human
Target:METTL1
Synonyms:Methyltransferase-Like 1, TRM8, tRNA(m7G46)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase , C12orf1, YDL201w, D1075-like gene product, FLJ95748, EC 2.1.1.33.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The METTL1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT, 50mM NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH

METTL1 is recognized as tRNA (guanine-N(7)-)-methyltransferase that is a part of the methyltransferase superfamily. METTL1 displays high sequence similarity to yeast ORF YDL201w and can be inactivated by phosphorylation. METTL1 protein has a conserved S-adenosylmethionine-binding motif and ccatalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Recombinant Human METTL1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (1-276a.a.) and having a molecular mass of 33.6kDa.METTL1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
NCBI Summary:This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBP6
NCBI GenInfo Identifier:32171926
NCBI Gene ID:4234
NCBI Accession:Q9UBP6.1
UniProt Secondary Accession:Q9UBP6,Q14105, Q53FS9, B2RBX1, H7BXF2,
UniProt Related Accession:Q9UBP6
Molecular Weight:17,423 Da
NCBI Full Name:tRNA (guanine-N(7)-)-methyltransferase
NCBI Synonym Full Names:methyltransferase like 1
NCBI Official Symbol:METTL1  
NCBI Official Synonym Symbols:TRM8; TRMT8; C12orf1; YDL201w  
NCBI Protein Information:tRNA (guanine-N(7)-)-methyltransferase
UniProt Protein Name:tRNA (guanine-N(7)-)-methyltransferase
UniProt Synonym Protein Names:Methyltransferase-like protein 1
UniProt Gene Name:METTL1  
UniProt Entry Name:TRMB_HUMAN
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