Human MESDC2 Recombinant Protein (RPPB3961)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB3961
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MESDC2
Synonyms:
LDLR chaperone MESD
Synonyms:
Mesoderm development candidate 2
Synonyms:
Mesoderm development protein
Synonyms:
Renal carcinoma antigen NY-REN-61
Source:
Escherichia Coli
Uniprot:
Q14696
€0.00
Frequently bought together:

Description

Product Name:Human MESDC2 Recombinant Protein
Product Code:RPPB3961
Size:10µg
Species:Human
Target:MESDC2
Synonyms:LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD, BOCA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MESDC2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAEGSPGTPD ESTPPPRKKK KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPVD FSKIDPSKPE SILKMTKKGK TLMMFVTVSG SPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGSYAWEIKD FLVGQDRCAD VTLEGQVYPG KGGGSKEKNK TKQDKGKKKK EGDLKSRSSK EENRAGNKRE DL

Mesoderm development candidate 2 (MESDC2) is required for formation of the primitive streak and mesoderm during embryogenesis. MESDC2 binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper folding and cell surface expression.

MESDC2 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (34-234 a.a.) and having a molecular mass of 24.9kDa (Molecular weight on SDS-PAGE will appear higher). The MESDC2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:MESDC2: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q13

Biological Process: protein folding

UniProt Code:Q14696
NCBI GenInfo Identifier:24418861
NCBI Gene ID:23184
NCBI Accession:Q14696.2
UniProt Secondary Accession:Q14696,Q969U1, B4DW84, D3DW96,
UniProt Related Accession:Q14696
Molecular Weight:14,895 Da
NCBI Full Name:LDLR chaperone MESD
NCBI Synonym Full Names:mesoderm development candidate 2
NCBI Official Symbol:MESDC2  
NCBI Official Synonym Symbols:BOCA; MESD  
NCBI Protein Information:LDLR chaperone MESD
UniProt Protein Name:LDLR chaperone MESD
UniProt Synonym Protein Names:Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
Protein Family:LDLR chaperone
UniProt Gene Name:MESDC2  
UniProt Entry Name:MESD_HUMAN
View AllClose

Related Products