Human MBIP Recombinant Protein (RPPB3936)

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SKU:
RPPB3936
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MBIP
Synonyms:
MAP3K12 binding inhibitory protein 1
Synonyms:
MAPK upstream kinase-binding inhibitory protein
Synonyms:
MUK-binding inhibitory protein
Synonyms:
MBIP
Source:
Escherichia Coli
Uniprot:
Q9NS73
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Description

Product Name:Human MBIP Recombinant Protein
Product Code:RPPB3936
Size:20µg
Species:Human
Target:MBIP
Synonyms:MAP3K12 binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein, MBIP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MBIP solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAATEL NRPSSGDRNL ERRCRPNLSR EVLYEIFRSL HTLVGQLDLR DDVVKITIDW NKLQSLSAFQ PALLFSALEQ HILYLQPFLA KLQSPIKEEN TTAVEEIGRT EMGNKNEVND KFSIGDLQEE EKHKESDLRD VKKTQIHFDP EVVQIKAGKA EIDRRISAFI ERKQAEINEN NVREFCNVID CNQENSCART DAIFTPYPGF KSHVKVSRVV NTYGPQTRPE GIPGSGHKPN SMLRDCGNQA VEERLQNIEA HLRLQTGGPV PRDIYQRIKK LEDKILELEG ISPEYFQSVS FSGKRRKVQP PQQNYSLAEL DEKISALKQA LLRKSREAES MATHHLP

MAP3K12 Binding Inhibitory Protein 1 (MBIP) is a part of the ATAC complex which consists of histones H3 and H4 with a histone acetyltransferase activity. MBIP inhibits the MAP3K12 activity in order to induce the activation of the JNK/SAPK pathway.

MBIP Human Recombinant produced in E. coli is a single polypeptide chain containing 367 amino acids (1-344) and having a molecular mass of 41.7kDa. MBIP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MBIP: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q13.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:identical protein binding; protein binding; protein kinase inhibitor activity

Biological Process: inactivation of MAPK activity during osmolarity sensing

UniProt Code:Q9NS73
NCBI GenInfo Identifier:7416858
NCBI Gene ID:51562
NCBI Accession:BAA94083.1
UniProt Secondary Accession:Q9NS73,Q86TZ2, Q96AS5, Q9BS93, Q9NZE1,
UniProt Related Accession:Q9NS73
Molecular Weight:Observed MW: 39 kDa
NCBI Full Name:MBIP
NCBI Synonym Full Names:MAP3K12 binding inhibitory protein 1
NCBI Official Symbol:MBIP  
NCBI Protein Information:MAP3K12-binding inhibitory protein 1
UniProt Protein Name:MAP3K12-binding inhibitory protein 1
UniProt Synonym Protein Names:MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein
Protein Family:MAP3K12-binding inhibitory protein
UniProt Gene Name:MBIP  
UniProt Entry Name:MBIP1_HUMAN
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