Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Product Name:
Human LYVE1/HAR Recombinant Protein (RPES3998)
Product Code:
RPES3998
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, LYVE-1, Cell Surface Retention Sequence-Binding Protein 1, CRSBP-1, Extracellular Link Domain-Containing Protein 1, Hyaluronic Acid Receptor, LYVE1, CRSBP1, HAR, XLKD1
Accession:
Q9Y5Y7
Sequence:
Leu20-Thr 238
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu20-Thr238 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
24.6 kDa
AP Mol Mass:
46 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris-Citrate,1 50mM NaCl, pH 7.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
